<?xml version="1.0"?>
<!DOCTYPE article
PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20190208//EN"
       "JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.4" xml:lang="en">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Journal of New Medical Technologies</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Journal of New Medical Technologies</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Вестник новых медицинских технологий</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">1609-2163</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">3633</article-id>
   <article-id pub-id-type="doi">10.12737/5926</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>Медицинская биофизика и разработка лечебно-диагностической аппаратуры</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>Medical Biophysics and Development of Treatment‐and‐Diagnostic Equipment</subject>
    </subj-group>
    <subj-group>
     <subject>Медицинская биофизика и разработка лечебно-диагностической аппаратуры</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">Cold Plasma Processing of Soft Tissues of the Joints: Model Tests on the Joint Rats</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Холодноплазменная обработка мягких тканей сустава: модельные испытания на суставе крыс</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Прудников</surname>
       <given-names>А.  В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Prudnikov</surname>
       <given-names>A.  В.</given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Новочадов</surname>
       <given-names>В.  В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Novochadov</surname>
       <given-names>V.  В.</given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Гайфулин</surname>
       <given-names>Н.  М.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Gayfulin</surname>
       <given-names>N.  М.</given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Маланин</surname>
       <given-names>Д.  А.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Malanin</surname>
       <given-names>D.  А.</given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Жуликов</surname>
       <given-names>А.  Л.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Zhulikov</surname>
       <given-names>A.  Л.</given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Батанов</surname>
       <given-names>В.  В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Batanov</surname>
       <given-names>V.  В.</given-names>
      </name>
     </name-alternatives>
    </contrib>
   </contrib-group>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2014-10-06T00:00:00+04:00">
    <day>06</day>
    <month>10</month>
    <year>2014</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2014-10-06T00:00:00+04:00">
    <day>06</day>
    <month>10</month>
    <year>2014</year>
   </pub-date>
   <volume>21</volume>
   <issue>3</issue>
   <fpage>159</fpage>
   <lpage>163</lpage>
   <self-uri xlink:href="https://naukaru.ru/en/nauka/article/3633/view">https://naukaru.ru/en/nauka/article/3633/view</self-uri>
   <abstract xml:lang="ru">
    <p>В работе проведен морфологический анализ влияния холодноплазменной обработки на заживление экспериментальных механических повреждений, сформированных в синовиальной оболочке, менисках и жировом теле в коленных суставах крыс. Для генерации холодной плазмы использован биполярный радиочастотный электрод «CoVac 50 Wand» аппарата «Atlas» (ArthroCare, США) в режимах 3 (150В, 68Вт) и 6 (225В, 160Вт), результаты заживления при спонтанной регенерации и после холодноплазменной обработки прослежены в течение 3 и 6 недель после повреждения. В качестве морфометрических показателей, свидетельствующих о положительном эффекте холодноплазменной обработки, были использованы определения фактора поверхности, расчетного объема регенерата (мм3) и численной плотности клеток в нем (1/мм3). В результате выявлен оптимальный эффект холодноплазменной обработки в режиме 6 (225В, 160Вт) для восстановления дефектов волокнистого хряща менисков и в режиме 3(150В, 68Вт) – для восстановления повреждений синовиальной оболочки и жирового тела суставов. Обработку жирового тела рекомендовано проводить максимально щадящим образом. Показано, что для мягких тканей не характерен феномен «сглаживания-заваривания», а холодноплазменная обработка даже в оптимальных режимах лишь способствует образованию более тонкого рубца на месте дефектов ткани. </p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>The effect of the radiofrequency ablation on the healing of experimental mechanical damage, formed in the synovium, menisci, and fat body in the rat knee joints was analyzed in this paper. To generate a cold plasma the bipolar radiofrequency electrode “CoVac 50 Wand” of apparatus ‘Atlas’ (ArthroCare, USA), applied in modes 3 (150 V, 68 W) and 6 (225 V, 160 W) was used. The results of the healing of the spontaneous regeneration and after cold ablation monitored within 3 and 6 weeks after the injury were presented. Dimensionless surface factor, estimated volume of the regeneration, and numerical density of cells was used to prove morphologically the beneficial effect of radiofrequency ablation. As a result, the optimal effect of this impact procedure was shown in respect of the restoration of meniscus defects in mode of 6 (225 V, 160 W) and the restoration of synovium and fat body defects in mode of 3 (150 V, 68 W). It was recommended the treatment of fat body by gentle way. It was shown that the phenomenon of «smoothing-maker» doesn’t typical for the soft tissues, and coblative processing even in an optimal mode only contributes to the formation of a thin scar in the place of tissue defects.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>суставной хрящ</kwd>
    <kwd>мениски</kwd>
    <kwd>жировое тело</kwd>
    <kwd>синовиальная оболочка</kwd>
    <kwd>холодноплазменная обработка</kwd>
    <kwd>морфология.</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>hyaline cartilage</kwd>
    <kwd>meniscus</kwd>
    <kwd>fat body</kwd>
    <kwd>synovium</kwd>
    <kwd>radiofrequency ablation</kwd>
    <kwd>morphology</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Жуликов А.Л., Маланин Д.А., Новочадов В.В. Применение холодноплазменной аблации для вос-становления поврежденных суставных поверхностей: модельные испытания // Вестник новых мед. технологий. 2009. Т. 16. №3. С. 104-105.</mixed-citation>
     <mixed-citation xml:lang="en">Zhulikov A.L., Malanin D.A., Novochadov V.V. Primenenie kholodnoplazmennoy ablatsii dlya vos-stanovleniya povrezhdennykh sustavnykh poverkhnostey: model&amp;#180;nye ispytaniya. Vestnik novykh med. tekhnologiy. 2009. T. 16. №3. S. 104-105.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Маланин Д.А., Жуликов А.Л., Новочадов В.В.  Морфологическая характеристика регенератов после холодноплазменной обработки эксперементальных неполнослойных повреждений гиалинового хряща // Вест-ник ВолГУ. Серия 11: Естественные науки. 2011. №2. С. 8-16.</mixed-citation>
     <mixed-citation xml:lang="en">Malanin D.A., Zhulikov A.L., Novochadov V.V.  Morfologicheskaya kharakteristika regeneratov posle kholodnoplazmennoy obrabotki eksperemental&amp;#180;nykh nepolnosloynykh povrezhdeniy gialinovogo khryashcha. Vest-nik VolGU. Seriya 11: Estestvennye nauki. 2011. №2. S. 8-16.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Орлецкий А.К., Езеев А.Р. Сравнительная оценка использования высокочастотной аблации при поврежде-нии капсульно-связочного аппарата коленного сустава у спортсменов // Мед. помощь. 2008. №4. С. 22-27.</mixed-citation>
     <mixed-citation xml:lang="en">Orletskiy A.K., Ezeev A.R. Sravnitel&amp;#180;naya otsenka ispol&amp;#180;zovaniya vysokochastotnoy ablatsii pri povrezhde-nii kapsul&amp;#180;no-svyazochnogo apparata kolennogo sustava u sportsmenov. Med. pomoshch&amp;#180;. 2008. №4. S. 22-27.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Debridment with an arthroscopic radiofrequence wand versus an arthroscopic shaver: соmparative effects on menisci and underlying articular cartilage / Allen T.R., Tasto J.P., Cummings J. [et al.] // Arthroscopy. 2006. N4. P. 385</mixed-citation>
     <mixed-citation xml:lang="en">Debridment with an arthroscopic radiofrequence wand versus an arthroscopic shaver: somparative effects on menisci and underlying articular cartilage / Allen T.R., Tasto J.P., Cummings J. [et al.]. Arthroscopy. 2006. N4. P. 385</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Amiel D., Ball S.T., Tasto J.P. Chondrocyte viability and metabolic activity after treatment of bovine articular cartilage with bipolar radiofrequency: an in vitro study // Arthroscopy. 2004. Vol. 5. P. 503-510.</mixed-citation>
     <mixed-citation xml:lang="en">Amiel D., Ball S.T., Tasto J.P. Chondrocyte viability and metabolic activity after treatment of bovine articular cartilage with bipolar radiofrequency: an in vitro study. Arthroscopy. 2004. Vol. 5. P. 503-510.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">An Y.H., Martin K.L. Handbook of histology methods for bone and cartilage. N.-Y.: Humana Press, 2003. 587 p.</mixed-citation>
     <mixed-citation xml:lang="en">An Y.H., Martin K.L. Handbook of histology methods for bone and cartilage. N.-Y.: Humana Press, 2003. 587 p.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Impact of monopolar radiofrequency energy on sub-chondral bone viability / Balcarek P., Kuhn A., Weigel A. [et al.] // Knee Surg. Sports Traumatol. Arthrosc. 2010. Vol. 18. N5. P. 673-680.</mixed-citation>
     <mixed-citation xml:lang="en">Impact of monopolar radiofrequency energy on sub-chondral bone viability / Balcarek P., Kuhn A., Weigel A. [et al.]. Knee Surg. Sports Traumatol. Arthrosc. 2010. Vol. 18. N5. P. 673-680.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Comparison of radiofrequency treatment and mechanical debridement of fibrillated cartilage in an equine model / Edwards R.B., Lu Y., Cole B.J. [et al.] // Vet. Comp. Orthop. Traumatol. 2008. Vol. 21. N1. P. 41-48.</mixed-citation>
     <mixed-citation xml:lang="en">Comparison of radiofrequency treatment and mechanical debridement of fibrillated cartilage in an equine model / Edwards R.B., Lu Y., Cole B.J. [et al.]. Vet. Comp. Orthop. Traumatol. 2008. Vol. 21. N1. P. 41-48.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Histopomorphic evaluation of radiofrequency mediated débridement chondroplasty / Ganguly K., McRury I.D., Goodwin P.M. [et al.] // Open Orthop. J. 2010. N4. P. 211-220.</mixed-citation>
     <mixed-citation xml:lang="en">Histopomorphic evaluation of radiofrequency mediated débridement chondroplasty / Ganguly K., McRury I.D., Goodwin P.M. [et al.]. Open Orthop. J. 2010. N4. P. 211-220.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Horstman C.L., McLaughlin  R.M. The use of radiofrequency energy during arthroscopic surgery and its effects on intraarticular tissues // Vet. Comp. Orthop. Traumatol. 2006. Vol. 19. N2. P. 65-71.</mixed-citation>
     <mixed-citation xml:lang="en">Horstman C.L., McLaughlin  R.M. The use of radiofrequency energy during arthroscopic surgery and its effects on intraarticular tissues. Vet. Comp. Orthop. Traumatol. 2006. Vol. 19. N2. P. 65-71.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ex vivo comparison of mechanical versus thermal chondroplasty: assessment of tissue effect at the surgical endpoint. / Lotto M.L., Wright E.J., Appleby D. [et al.] // Arthroscopy. 2008. Vol. 24. N4. P. 410-415</mixed-citation>
     <mixed-citation xml:lang="en">Ex vivo comparison of mechanical versus thermal chondroplasty: assessment of tissue effect at the surgical endpoint. / Lotto M.L., Wright E.J., Appleby D. [et al.]. Arthroscopy. 2008. Vol. 24. N4. P. 410-415</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Outcomes of mechanical debridement and radiofre-quency ablation in the treatment of chondral defects: a prospective randomized study / Richard W., Kang W., Andreas H. [et al.] // Knee Surg. 2008. Vol. 28. P. 116-121.</mixed-citation>
     <mixed-citation xml:lang="en">Outcomes of mechanical debridement and radiofre-quency ablation in the treatment of chondral defects: a prospective randomized study / Richard W., Kang W., Andreas H. [et al.]. Knee Surg. 2008. Vol. 28. P. 116-121.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Arthroscopic knee chondroplasty using a bipolar radiofrequency-based device compared to mechanical shaver: results of a prospective, randomized, controlled study / Spahn G., Kahl E., Muckley T. [et al.] // Knee Surg. Sports Traumatol. Arthrosc. 2008. Vol. 16. P. 565-573.</mixed-citation>
     <mixed-citation xml:lang="en">Arthroscopic knee chondroplasty using a bipolar radiofrequency-based device compared to mechanical shaver: results of a prospective, randomized, controlled study / Spahn G., Kahl E., Muckley T. [et al.]. Knee Surg. Sports Traumatol. Arthrosc. 2008. Vol. 16. P. 565-573.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Cartilage repair: past and future - lessons for regenerative medicine / Van Osch G.J., Brittberg M., Dennis J.E. [et al.] // J. Cell Mol. Med. 2009. Vol. 13. N5. P. 792-810.</mixed-citation>
     <mixed-citation xml:lang="en">Cartilage repair: past and future - lessons for regenerative medicine / Van Osch G.J., Brittberg M., Dennis J.E. [et al.]. J. Cell Mol. Med. 2009. Vol. 13. N5. P. 792-810.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Zoric B.B., Horn N., Braun S., Millett P.J. Factors in-fluencing intra-articular fluid temperature profiles with radiofrequency ablation // J. Bone Joint Surg. Am. 2009. Vol. 91. N10. P. 2448-2454.</mixed-citation>
     <mixed-citation xml:lang="en">Zoric B.B., Horn N., Braun S., Millett P.J. Factors in-fluencing intra-articular fluid temperature profiles with radiofrequency ablation. J. Bone Joint Surg. Am. 2009. Vol. 91. N10. P. 2448-2454.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Хадарцев А.А., Яшин А.А., Еськов В.М., Агарков Н.М., Кобринский Б.А., Фролов М.В., Чухраев А.М., Гондарев С.Н., Хромушин В.А., Каменев Л.И., Валентинов Б.Г., Агаркова Д.И. Информационные  технологии  в  медицине. Монография. Тула: ТулГУ, 2006. 272 с.</mixed-citation>
     <mixed-citation xml:lang="en">Khadartsev A.A., Yashin A.A., Es&amp;#180;kov V.M., Agarkov N.M., Kobrinskiy B.A., Frolov M.V., Chukhraev A.M., Gondarev S.N., Khromushin V.A., Kamenev L.I., Valentinov B.G., Agarkova D.I. Informatsionnye  tekhnologii  v  meditsine. Monografiya. Tula: TulGU, 2006. 272 s.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
