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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Acta biomedica scientifica</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Acta biomedica scientifica</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Acta biomedica scientifica</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2541-9420</issn>
   <issn publication-format="online">2587-9596</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">17250</article-id>
   <article-id pub-id-type="doi">10.12737/article_5955e6b60d5bf2.66416553</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>обзоры</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>Review</subject>
    </subj-group>
    <subj-group>
     <subject>обзоры</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>САХАРНЫЙ ДИАБЕТ 2-ГО ТИПА И ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Бардымова</surname>
       <given-names>Татьяна Прокопьевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Bardymova</surname>
       <given-names>Tatyana Prokopyevna</given-names>
      </name>
     </name-alternatives>
     <email>tpbardymova@mail.ru</email>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Протасов</surname>
       <given-names>Константин Викторович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Protasov</surname>
       <given-names>Konstantin Viktorovich</given-names>
      </name>
     </name-alternatives>
     <email>k.v.protasov@gmail.ru</email>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Цыреторова</surname>
       <given-names>Сэсэг Самбуевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Tsyretorova</surname>
       <given-names>Seseg Sambuevna</given-names>
      </name>
     </name-alternatives>
     <email>tsyretorova.seseg@yandex.ru</email>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Донирова</surname>
       <given-names>Оюна Сергеевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Donirova</surname>
       <given-names>Oyuna Sergeevna</given-names>
      </name>
     </name-alternatives>
     <email>donirova@mail.ru</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Иркутская государственная медицинская академия последипломного образования</institution>
     <city>Иркутск</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Irkutsk State Medical Academy of Postgraduate Education</institution>
     <city>Irkutsk</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Иркутская государственная медицинская академия последипломного образования</institution>
     <city>Иркутск</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Irkutsk State Medical Academy of Postgraduate Education</institution>
     <city>Irkutsk</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Республиканская клиническая больница им. Н.А. Семашко</institution>
     <city>Улан-Удэ</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">N.A. Semashko Republic Clinical Hospital</institution>
     <city>Ulan-Ude</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <volume>2</volume>
   <issue>1</issue>
   <fpage>100</fpage>
   <lpage>106</lpage>
   <self-uri xlink:href="https://naukaru.ru/en/nauka/article/17250/view">https://naukaru.ru/en/nauka/article/17250/view</self-uri>
   <abstract xml:lang="ru">
    <p>Сахарный диабет приобретает масштабы эпидемии. Наблюдается рост числа больных ишемической&#13;
болезнью сердца, страдающих сахарным диабетом 2-го типа. При наличии сахарного диабета усугубляется&#13;
течение ишемической болезни сердца в виду прогрессирования атеросклероза. В развитии атеросклероза&#13;
отмечается роль цитокинов, которые являются отражением местного и системного воспаления.&#13;
Инсулинорезистентность, гиперфибриногенемия, дислипидемиия у больных сахарным диабетом усиливают&#13;
риск неблагоприятных исходов ишемической болезни сердца.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Сахарный диабет приобретает масштабы эпидемии. Наблюдается рост числа больных ишемической&#13;
болезнью сердца, страдающих сахарным диабетом 2-го типа. При наличии сахарного диабета усугубляется&#13;
течение ишемической болезни сердца в виду прогрессирования атеросклероза. В развитии атеросклероза&#13;
отмечается роль цитокинов, которые являются отражением местного и системного воспаления.&#13;
Инсулинорезистентность, гиперфибриногенемия, дислипидемиия у больных сахарным диабетом усиливают&#13;
риск неблагоприятных исходов ишемической болезни сердца.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>сахарный диабет 2-го типа</kwd>
    <kwd>ишемическая болезнь сердца</kwd>
    <kwd>дисфункция эндотелия</kwd>
    <kwd>цитокины</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Бардымова Т.П., Колесникова Л.И., Петрова В.А. Перекисное окисление липидов и антиоксидантная система у больных сахарным диабетом 2-го типа // Бюллетень ВСНЦ СО РАМН. - 2005. - № 6. - С. 11-14.</mixed-citation>
     <mixed-citation xml:lang="en">Bardymova TP, Kolesnikova LI, Petrova VA. (2005). Lipid peroxidation and antioxidation system in patients with type 2 diabetes mellitus [Perekisnoe okislenie lipidov i antioksidantnaya sistema u bol’nykh sakharnym diabetom 2-go tipa]. Bulleten’ Vostocno-Sibirskogo naucnogo centra, (6), 11-14.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Горюшкина О.А., Васильева Е.М. Антиоксидантная терапия в коррекции оксидативного стресса у больных ишемической болезнью сердца с сахарным диабетом 2-го типа // Вестник новых медицинских технологий. - 2013. - № 2. - С. 156-158.</mixed-citation>
     <mixed-citation xml:lang="en">Goryushkina OA, Vasilyeva EM. (2013). Antioxidant therapy in the correction of oxidative stress in the patients with coronary heart disease and type 2 diabetes mellitus [Antioksidantnaya terapiya v korrektsii oksidativnogo stressa u bol’nykh ishemicheskoy bolezn’yu serdtsa s sakharnym diabetom 2-go tipa]. Vestnik novykh meditsinskikh tekhnologiy, (2), 156-158.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Грачева С.А., Клефортова И.И., Шамхалова М.Ш. Распространённость сочетанного атеросклеротического поражения сосудов у больных сахарным диабетом // Сахарный диабет. - 2012. - № 1. - С. 49-55.</mixed-citation>
     <mixed-citation xml:lang="en">Gracheva SA, Klefortova II, Shamкhalova MS. (2015). Prevalence of combined atherosclerotic vascular lesions in patients with diabetes mellitus [Rasprostranennost’ sochetannogo ateroskleroticheskogo porazheniya sosudov u bol’nykh sakharnym diabetom]. Sakharnyy diabet, (1), 49-55.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Дедов И.И., Шестакова М.В., Викулова О.К. Государственный регистр сахарного диабета в Российской Федерации: статус 2014 г. и перспективы развития // Сахарный диабет. - 2015. - № 3. - С. 5-23.</mixed-citation>
     <mixed-citation xml:lang="en">Dedov II, Shestakova MV, Vikulova OK. (2015). National register of diabetes mellitus in Russian Federation: status on 2014 [Gosudarstvennyy registr sakharnogo dia beta v Rossiyskoy Federatsii: status 2014 g. i perspektivy razvitiya]. Sakharnyy diabet, (3), 5-23.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Донцов А.В., Васильева Л.В. Инсулинорезистентность при метаболическом синдроме как показатель сердечно-сосудистого риска // Клиническая медицина. - 2016. - № 3. - С. 189-193.</mixed-citation>
     <mixed-citation xml:lang="en">Dontsov AV, Vasil’eva LV. (2016). Insulin resistance associated with metabolic syndrome as an indicator of cardiovascular risk [Insulinorezistentnost’ pri metabolicheskom sindrome kak pokazatel’ serdechno-sosudistogo riska]. Klinicheskaya meditsina, (3), 189-193.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Доскина Е.В. Причины неудач в компенсации пациентов с сахарным диабетом 2-го типа. Роль постпрандиальной гликемии // Сахарный диабет. - 2010. - № 1. - С. 129-132.</mixed-citation>
     <mixed-citation xml:lang="en">Doskina EV. (2010). Causes behind the failure to manage patients with type 2 diabetes mellitus. The role of postprandial glycemia [Prichiny neudach v kompensatsii patsientov s sakharnym diabetom 2-go tipa. Rol’ postprandial’noy glikemii]. Sakharnyy diabet, (1), 129-132.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Закирова Н.Э., Хафизов Н.Х., Карамова И.М., Закирова А.Н., Оганов Р.Г. Иммуновоспалительные реакции при ишемической болезни сердца // Рациональная фармакотерапия в кардиологии. - 2007. - № 2. - С. 16-19.</mixed-citation>
     <mixed-citation xml:lang="en">Zakirova NE, Khafizov NK, Karamova IM, Zakirova AN, Oganov RG. (2007). Immunological reaction in coronary heart disease [Immunovospalitel’nye reaktsii pri ishemicheskoy bolezni serdtsa]. Ratsional’naya farmakoterapiya v kardiologii, (2), 16-19.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Литвинова Л.С., Кириенкова Е.В., Аксенова Н.Н., Газатова Н.Д., Затолокин П.А. Особенности клеточного иммунитета и цитокинового репертуара у пациентов с метаболическим синдромом // Бюллетень сибирской медицины. - 2012. - № 3. - С. 53-58.</mixed-citation>
     <mixed-citation xml:lang="en">Litvinova LS, Kiriyenkova YV, Aksyonova NN, Gazatova ND, Zatolokin PA. (2012). Features of cellular immunity and cytokine repertoire in patients with metabolic syndrome [Osobennosti kletochnogo immuniteta i tsitokinovogo repertuara u patsientov s metabolicheskim sindromom]. Byulleten’ sibirskoy meditsiny, (3), 53-58.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Сахарный диабет 2-го типа: от теории к практике / Под ред. И.И. Дедова, М.В. Шестаковой. - М.: МИА, 2016. - 571 с.</mixed-citation>
     <mixed-citation xml:lang="en">Dedov II, Shestakova MV (ed.). (2016). Type 2 diabetes mellitus: from theory to practice [Sakharnyy diabet 2-go tipa: ot teorii k praktike]. Moskva, 571 p.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Шварц В. Воспаление жировой ткани. Часть 2. Патогенетическая роль при сахарном диабете 2-го типа // Проблемы эндокринологии. - 2009. - № 5. - С. 43-48.</mixed-citation>
     <mixed-citation xml:lang="en">Shvarts V. (2009). Inflammation of adipose tissue. Part 2. Pathogenic role at type 2 diabetes mellitus [Vospalenie zhirovoy tkani. Chast’ 2. Patogeneticheskaya rol’ pri sakharnom diabete 2-go tipa]. Problemy endokrinologii, (5), 43-48.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Шестакова М.В., Чазова И.Е., Шестакова Е.А. Российское многоцентровое скрининговое исследование по выявлению недиагностированного сахарного диабета 2-го типа у пациентов с сердечно-сосудистой патологией // Сахарный диабет. - 2016. - № 1. - С. 24-29.</mixed-citation>
     <mixed-citation xml:lang="en">Shestakova МV, Chazova IE, Shestakova EA. (2016). Russian multicentre screening program for revealing undiagnosed type 2 diabetes mellitus in patients with cardiovascular disease [Rossiyskoe mnogotsentrovoe skriningovoe issledovanie po vyyavleniyu nediagnostirovannogo sakharnogo diabeta 2-go tipa u patsientov s serdechno-sosudistoy patologiey]. Sakharnyy diabet, (1), 24-29.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Эссенциальная артериальная гипертензия и гены ренинангиотензиновой системы / Под ред. Л.И. Колесниковой. - Новосибирск: Наука, 2008. - 108 с.</mixed-citation>
     <mixed-citation xml:lang="en">Kolesnikova LI (ed.). (2008). Essential hypertension and genes of the renin angiotensin system [Essentsial’naya arterial’naya gipertenziya i geny reninangiotenzinovoy sistemy]. Novosibirsk, 108 p.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Abbatecola AM, Paolisso G, Sinclair AJ. (2015). Treating diabetes mellitus in older and oldest old people. Curr. Pharm. Des., 21, 1665-1671.</mixed-citation>
     <mixed-citation xml:lang="en">Abbatecola AM, Paolisso G, Sinclair AJ. (2015). Treating diabetes mellitus in older and oldest old people. Curr. Pharm. Des., 21, 1665-1671.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Amar J, Fauvel J, Drouet L, Ruidavets JB, Perret B, Chamontin B, Boccalon H, Ferrieres J. (2006). Interleukin 6 is associated with subclinical atherosclerosis: a link with soluble intercellular adhesion molecule 1. J. Hypertens., 6, 1083-1088.</mixed-citation>
     <mixed-citation xml:lang="en">Amar J, Fauvel J, Drouet L, Ruidavets JB, Perret B, Chamontin B, Boccalon H, Ferrieres J. (2006). Interleukin 6 is associated with subclinical atherosclerosis: a link with soluble intercellular adhesion molecule 1. J. Hypertens., 6, 1083-1088.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Antoniades C, Tousoulis D, Tountas C, Tentolouris C, Toutouza M, Vasiliadou C, Tsioufis C, Toutouzas P, Stefanadis C. (2004). Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C. Diabet. Med., 6, 552-558.</mixed-citation>
     <mixed-citation xml:lang="en">Antoniades C, Tousoulis D, Tountas C, Tentolouris C, Toutouza M, Vasiliadou C, Tsioufis C, Toutouzas P, Stefanadis C. (2004). Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C. Diabet. Med., 6, 552-558.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N. (2004). Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic. Biol. Med., 37, 755-767.</mixed-citation>
     <mixed-citation xml:lang="en">Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N. (2004). Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic. Biol. Med., 37, 755-767.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B17">
    <label>17.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, Fonseca V, Gerstein HC, Grundy S, Nesto RW, Pignone MP, Plutzky J, Porte D, Redberg R, Stitzel KF, Stone NJ; American Heart Association; American Diabetes Association. (2007). Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation, 115 (1), 114-126.</mixed-citation>
     <mixed-citation xml:lang="en">Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, Fonseca V, Gerstein HC, Grundy S, Nesto RW, Pignone MP, Plutzky J, Porte D, Redberg R, Stitzel KF, Stone NJ; American Heart Association; American Diabetes Association. (2007). Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation, 115 (1), 114-126.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B18">
    <label>18.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chuengsamarn S, Rattanamongkolgul S, Sittithumcharee G, Jirawatnotai S. (2016). Association of serum high-sensitivity C-reactive protein with metabolic control and diabetic chronic vascular complications in patients with type 2 diabetes. Diabetes Metab. Syndr., 16, 30141-30142.</mixed-citation>
     <mixed-citation xml:lang="en">Chuengsamarn S, Rattanamongkolgul S, Sittithumcharee G, Jirawatnotai S. (2016). Association of serum high-sensitivity C-reactive protein with metabolic control and diabetic chronic vascular complications in patients with type 2 diabetes. Diabetes Metab. Syndr., 16, 30141-30142.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B19">
    <label>19.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Cubbon RM, Adams B, Rajwani A, Mercer BN, Patel PA, Cherardi G, Gale CP, Batin PD, Ajjan R, Kearney L, Wheatcroft SB, Sapsford RJ, Witte KK, Kearney MT. (2013). Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemicaetiology. Diab. Vasc. Dis. Res., 10 (4), 330-336.</mixed-citation>
     <mixed-citation xml:lang="en">Cubbon RM, Adams B, Rajwani A, Mercer BN, Patel PA, Cherardi G, Gale CP, Batin PD, Ajjan R, Kearney L, Wheatcroft SB, Sapsford RJ, Witte KK, Kearney MT. (2013). Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemicaetiology. Diab. Vasc. Dis. Res., 10 (4), 330-336.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B20">
    <label>20.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Deedwania PC. (2003). Diabetes and vascular disease: common links in the emerging epidemic of coronary artery disease. Am. J. Cardiol., 91 (1), 68-71.</mixed-citation>
     <mixed-citation xml:lang="en">Deedwania PC. (2003). Diabetes and vascular disease: common links in the emerging epidemic of coronary artery disease. Am. J. Cardiol., 91 (1), 68-71.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B21">
    <label>21.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Dinarello CA. (2006). Interleukin 1 beta and interleukin 18 as mediators of inflammation and the aging process. Am. J. Clin. Nutr., 83 (2), 447-455.</mixed-citation>
     <mixed-citation xml:lang="en">Dinarello CA. (2006). Interleukin 1 beta and interleukin 18 as mediators of inflammation and the aging process. Am. J. Clin. Nutr., 83 (2), 447-455.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B22">
    <label>22.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). (2001). JAMA, 285, 2486-2497.</mixed-citation>
     <mixed-citation xml:lang="en">Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). (2001). JAMA, 285, 2486-2497.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B23">
    <label>23.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Galis ZS, Sukhova GK, Lark MW, Libby P. (1994). Increased expression of matrix matalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerosis plaques. J. Clin. Invest., 94 (6), 2493-2503.</mixed-citation>
     <mixed-citation xml:lang="en">Galis ZS, Sukhova GK, Lark MW, Libby P. (1994). Increased expression of matrix matalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerosis plaques. J. Clin. Invest., 94 (6), 2493-2503.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B24">
    <label>24.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Garcia C, Feve B, Ferré P, Halimi S, Baizri H, Bordier L, Guiu G, Dupuy O, Bauduceau B, Mayaudon H. (2010). Diabetes and inflammation: fundamental aspects and clinical implications. Diabetes Metab., 36 (5), 327-338.</mixed-citation>
     <mixed-citation xml:lang="en">Garcia C, Feve B, Ferré P, Halimi S, Baizri H, Bordier L, Guiu G, Dupuy O, Bauduceau B, Mayaudon H. (2010). Diabetes and inflammation: fundamental aspects and clinical implications. Diabetes Metab., 36 (5), 327-338.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B25">
    <label>25.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Greenland P, Abrams J, Aurigemma GP, Bond MG, Clark LT, Criqui MH, Crouse JR 3rd, Friedman L, Fuster V, Herrington DM, Kuller LH, Ridker PM, Roberts WC, Stanford W, Stone N, Swan HJ, Taubert KA, Wexler L. (2000). Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. Circulation, 101, 16-22.</mixed-citation>
     <mixed-citation xml:lang="en">Greenland P, Abrams J, Aurigemma GP, Bond MG, Clark LT, Criqui MH, Crouse JR 3rd, Friedman L, Fuster V, Herrington DM, Kuller LH, Ridker PM, Roberts WC, Stanford W, Stone N, Swan HJ, Taubert KA, Wexler L. (2000). Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. Circulation, 101, 16-22.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B26">
    <label>26.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Gulli G, Ferrannini E, Stern M, Haffner S, DeFronzo RA (1992) The metabolic profile of NIDDM is fully established in glucose tolerant offspring of two Mexican-American NIDDM parents. Diabetes, 41, 1575-1586.</mixed-citation>
     <mixed-citation xml:lang="en">Gulli G, Ferrannini E, Stern M, Haffner S, DeFronzo RA (1992) The metabolic profile of NIDDM is fully established in glucose tolerant offspring of two Mexican-American NIDDM parents. Diabetes, 41, 1575-1586.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B27">
    <label>27.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Haffner SM, Mykkänen L, Valdez RA, Stern MP, Holloway DL, Monterrosa A, Bowsher RR. (1994). Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome. J. Clin. Endocrinol. Metab., 79, 1806-1810.</mixed-citation>
     <mixed-citation xml:lang="en">Haffner SM, Mykkänen L, Valdez RA, Stern MP, Holloway DL, Monterrosa A, Bowsher RR. (1994). Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome. J. Clin. Endocrinol. Metab., 79, 1806-1810.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B28">
    <label>28.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Hotamisligil GS. (2006). Inflammation and metabolic disorders. Nature, 444 (7121), 860-867.</mixed-citation>
     <mixed-citation xml:lang="en">Hotamisligil GS. (2006). Inflammation and metabolic disorders. Nature, 444 (7121), 860-867.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B29">
    <label>29.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">IDF Diabetes Atlas, 7th ed. (2015). Available at: http://www.diabetesatlas.org/resources/2015-atlas.html.</mixed-citation>
     <mixed-citation xml:lang="en">IDF Diabetes Atlas, 7th ed. (2015). Available at: http://www.diabetesatlas.org/resources/2015-atlas.html.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B30">
    <label>30.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Iozzo P, Chareonthaitawee P, Dutka D, Betteridge DJ, Ferrannini E, Camici PG. (2002). Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance. Diabetes, 51, 3020-3024.</mixed-citation>
     <mixed-citation xml:lang="en">Iozzo P, Chareonthaitawee P, Dutka D, Betteridge DJ, Ferrannini E, Camici PG. (2002). Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance. Diabetes, 51, 3020-3024.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B31">
    <label>31.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Jialal I, Devaraj S, Venugopal SK. (2004). C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension, 44, 6-11.</mixed-citation>
     <mixed-citation xml:lang="en">Jialal I, Devaraj S, Venugopal SK. (2004). C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension, 44, 6-11.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B32">
    <label>32.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kendall M, Sobel BE, Coulston AM. (2003). The insulin resistance syndrome and coronary artery disease. Coron. Artery. Dis., 14 (4), 335-348.</mixed-citation>
     <mixed-citation xml:lang="en">Kendall M, Sobel BE, Coulston AM. (2003). The insulin resistance syndrome and coronary artery disease. Coron. Artery. Dis., 14 (4), 335-348.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B33">
    <label>33.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Lautamäki R, Airaksinen KE, Seppänen M, Toikka J, Luotolahti M, Ball E, Borra R, Härkönen R, Iozzo P, Stewart M, Knuuti J, Nuutila P. (2005). Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and coronary artery disease. Diabetes, 54, 2787-2794.</mixed-citation>
     <mixed-citation xml:lang="en">Lautamäki R, Airaksinen KE, Seppänen M, Toikka J, Luotolahti M, Ball E, Borra R, Härkönen R, Iozzo P, Stewart M, Knuuti J, Nuutila P. (2005). Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and coronary artery disease. Diabetes, 54, 2787-2794.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B34">
    <label>34.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Lee AY, Chung SS. (1999). Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J., 13, 23-30.</mixed-citation>
     <mixed-citation xml:lang="en">Lee AY, Chung SS. (1999). Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J., 13, 23-30.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B35">
    <label>35.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Maggioni AP, Anand I, Gottlieb SO. (2002). Effects of valsarían on morbidity and mortality in patients with heart failure not receiving angiotensin converting enzyme inhibitors. J. Am. Coll. Cardiol., 40, 1414-1421.</mixed-citation>
     <mixed-citation xml:lang="en">Maggioni AP, Anand I, Gottlieb SO. (2002). Effects of valsarían on morbidity and mortality in patients with heart failure not receiving angiotensin converting enzyme inhibitors. J. Am. Coll. Cardiol., 40, 1414-1421.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B36">
    <label>36.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Miyamoto S, Rubio M, Sussman MA. (2009). Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc. Res., 1, 272-285.</mixed-citation>
     <mixed-citation xml:lang="en">Miyamoto S, Rubio M, Sussman MA. (2009). Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc. Res., 1, 272-285.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B37">
    <label>37.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Muris DM, Houben AJ, Kroon AA, Henry RM, van der Kallen CJ, Sep SJ, Koster A, Dagnelie PC, Schram MT, Stehouwer CD. (2014). Age, waist circumference and blood pressure are associated with skin microvascular flow motion: the Maastricht Study. J. Hypertens., 32 (12), 2439-2449.</mixed-citation>
     <mixed-citation xml:lang="en">Muris DM, Houben AJ, Kroon AA, Henry RM, van der Kallen CJ, Sep SJ, Koster A, Dagnelie PC, Schram MT, Stehouwer CD. (2014). Age, waist circumference and blood pressure are associated with skin microvascular flow motion: the Maastricht Study. J. Hypertens., 32 (12), 2439-2449.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B38">
    <label>38.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Orchard TJ, Costacou T, Kretowski A, Nesto RW. (2006). Type 1 diabetes and coronary artery disease. Diabetes Care, 11, 2528-2538.</mixed-citation>
     <mixed-citation xml:lang="en">Orchard TJ, Costacou T, Kretowski A, Nesto RW. (2006). Type 1 diabetes and coronary artery disease. Diabetes Care, 11, 2528-2538.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B39">
    <label>39.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Prentki M, Nolan CJ. (2006). Islet β cell failure in type 2 diabetes. J. Clin. Invest., 116 (7), 1802-1812.</mixed-citation>
     <mixed-citation xml:lang="en">Prentki M, Nolan CJ. (2006). Islet β cell failure in type 2 diabetes. J. Clin. Invest., 116 (7), 1802-1812.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B40">
    <label>40.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ramana KV, Friedrich B, Tammali R, West MB, Bhatnagar A, Srivastava SK. (2005). Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes, 54, 818-829.</mixed-citation>
     <mixed-citation xml:lang="en">Ramana KV, Friedrich B, Tammali R, West MB, Bhatnagar A, Srivastava SK. (2005). Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes, 54, 818-829.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B41">
    <label>41.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Reaven GM. (1998). Role of insulin resistance in human disease. Diabetes, 37, 1595-1607.</mixed-citation>
     <mixed-citation xml:lang="en">Reaven GM. (1998). Role of insulin resistance in human disease. Diabetes, 37, 1595-1607.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B42">
    <label>42.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. (2000). Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation, 101, 1767-1772.</mixed-citation>
     <mixed-citation xml:lang="en">Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. (2000). Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation, 101, 1767-1772.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B43">
    <label>43.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Schauer IE, Shell-Bergeon JK, Bergman BC, Maahs DM, Kretowski A, Eckel RH, Revers M. (2011). Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study. Diabetes, 1, 306-314.</mixed-citation>
     <mixed-citation xml:lang="en">Schauer IE, Shell-Bergeon JK, Bergman BC, Maahs DM, Kretowski A, Eckel RH, Revers M. (2011). Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study. Diabetes, 1, 306-314.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B44">
    <label>44.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Splansky GL, Corey D, Yang Q, Atwood LD, Cupples LA, Benjamin EJ, D’Agostino RB Sr, Fox CS, Larson MG, Murabito JM, O’Donnell CJ, Vasan RS, Wolf PA, Levy D. (2007). The third generation cohort of the National Heart, Lung, and Blood Institute’s Framingham Heart Study: design, recruitment, and initial examination. Am. J. Epidemiol., 165, 1328-1335.</mixed-citation>
     <mixed-citation xml:lang="en">Splansky GL, Corey D, Yang Q, Atwood LD, Cupples LA, Benjamin EJ, D’Agostino RB Sr, Fox CS, Larson MG, Murabito JM, O’Donnell CJ, Vasan RS, Wolf PA, Levy D. (2007). The third generation cohort of the National Heart, Lung, and Blood Institute’s Framingham Heart Study: design, recruitment, and initial examination. Am. J. Epidemiol., 165, 1328-1335.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B45">
    <label>45.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR. (2000). Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective, observational study. BMJ, 321, 405-412.</mixed-citation>
     <mixed-citation xml:lang="en">Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR. (2000). Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective, observational study. BMJ, 321, 405-412.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B46">
    <label>46.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Tappia PS, Dent MR, Dhalla NS. (2006). Oxidative stress and redox regulation of phospholipase D in myocardial disease. Free Radic. Biol. Med., 41, 349-361.</mixed-citation>
     <mixed-citation xml:lang="en">Tappia PS, Dent MR, Dhalla NS. (2006). Oxidative stress and redox regulation of phospholipase D in myocardial disease. Free Radic. Biol. Med., 41, 349-361.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B47">
    <label>47.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Taubert D, Rosenkranz A, Berkels R, Roesen R, Schmig E. (2004). Acute effects of glucose and insulin on vascular endothelium. Diabetologia,  47, 2059-2071.</mixed-citation>
     <mixed-citation xml:lang="en">Taubert D, Rosenkranz A, Berkels R, Roesen R, Schmig E. (2004). Acute effects of glucose and insulin on vascular endothelium. Diabetologia,  47, 2059-2071.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B48">
    <label>48.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Uptitchard JE, Sutherland WH, Mann JI. (2000). Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Сare, 23, 733-738.</mixed-citation>
     <mixed-citation xml:lang="en">Uptitchard JE, Sutherland WH, Mann JI. (2000). Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Сare, 23, 733-738.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B49">
    <label>49.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Yilmaz MB, Guray U, Guray Y, Altay H, Demirkan B, Caldir V, Cay S, Refiker ME, Sasmaz H, Korkmaz S. (2005). Metabolic syndrome is associated with extension of coronary artery disease in patients with non-ST segment elevation acute coronary syndromes. Coron. Artery Dis., 100, 561-562.</mixed-citation>
     <mixed-citation xml:lang="en">Yilmaz MB, Guray U, Guray Y, Altay H, Demirkan B, Caldir V, Cay S, Refiker ME, Sasmaz H, Korkmaz S. (2005). Metabolic syndrome is associated with extension of coronary artery disease in patients with non-ST segment elevation acute coronary syndromes. Coron. Artery Dis., 100, 561-562.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B50">
    <label>50.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Young J, Libby P, Schonbeck U. (2002). Cytokines in the pathogenesis of atherosclerosis. Thrombos. Haemostas., 88, 554-567.</mixed-citation>
     <mixed-citation xml:lang="en">Young J, Libby P, Schonbeck U. (2002). Cytokines in the pathogenesis of atherosclerosis. Thrombos. Haemostas., 88, 554-567.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
