<?xml version="1.0"?>
<!DOCTYPE article
PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20190208//EN"
       "JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.4" xml:lang="en">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Acta biomedica scientifica</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Acta biomedica scientifica</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Acta biomedica scientifica</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2541-9420</issn>
   <issn publication-format="online">2587-9596</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">14500</article-id>
   <article-id pub-id-type="doi">10.12737/23393</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>морфология</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>morphology</subject>
    </subj-group>
    <subj-group>
     <subject>морфология</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">Proliferative activity of salivary tumor cells</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Пролиферативная активность клеток опухолей слюнных желез</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Немчинова</surname>
       <given-names>Светлана Владимировна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Nemchinova</surname>
       <given-names>Svetlana Владимировна</given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Раевская</surname>
       <given-names>Лидия Юрьевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Raevskaya</surname>
       <given-names>Lidiya Юрьевна</given-names>
      </name>
     </name-alternatives>
     <email> mkt@dc.baikal.ru</email>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Казимирский</surname>
       <given-names>Виктор Анатольевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Kazimirskiy</surname>
       <given-names>Viktor Анатольевич</given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Кислицина</surname>
       <given-names>Лада Юрьевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Kislitsina</surname>
       <given-names>Lada Юрьевна</given-names>
      </name>
     </name-alternatives>
     <email>cyto@iood.ru</email>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Алёшкин</surname>
       <given-names>Игорь Германович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Aleshkin</surname>
       <given-names>Igor Германович</given-names>
      </name>
     </name-alternatives>
     <email> aig64@mail.ru</email>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Батороев</surname>
       <given-names>Юрий Климентьевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Batoroev</surname>
       <given-names>Yuriy Климентьевич</given-names>
      </name>
     </name-alternatives>
     <email>ybatoroev@mail.ru</email>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Бычков</surname>
       <given-names>Дмитрий Владимирович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Bychkov</surname>
       <given-names>Dmitriy Владимирович</given-names>
      </name>
     </name-alternatives>
     <email> Bychkov-Dmitrij@yandex.ru</email>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Фильченкова</surname>
       <given-names>Елена Васильевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Filchenkova</surname>
       <given-names>Elena Васильевна</given-names>
      </name>
     </name-alternatives>
    </contrib>
   </contrib-group>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2016-12-09T00:00:00+03:00">
    <day>09</day>
    <month>12</month>
    <year>2016</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2016-12-09T00:00:00+03:00">
    <day>09</day>
    <month>12</month>
    <year>2016</year>
   </pub-date>
   <volume>1</volume>
   <issue>5</issue>
   <fpage>68</fpage>
   <lpage>70</lpage>
   <self-uri xlink:href="https://naukaru.ru/en/nauka/article/14500/view">https://naukaru.ru/en/nauka/article/14500/view</self-uri>
   <abstract xml:lang="ru">
    <p>Большое разнообразие морфологических вариантов значительно затрудняет цитологическую диагностику опухолей слюнных желез. Одной из характерных особенностей раковых клеток большинства новообразований является их высокая пролиферативная активность. Митотический индекс, индекс Ki-67 статистически значимо выше в злокачественных опухолях (p&amp;#60;0,05). Его определение в совокупности с традиционным цитологическим исследованием повышает точность дифференциальной диагностики между доброкачественными и злокачественными опухолями слюнных желез.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Salivary carcinomas comprise 2–3 % of malignant tumors of the head and neck. The basic method of morphological study in early diagnostics is aspiration puncture with a fine needle (FNAB). Complex histologic structure and great diversity of morphological items complicate cytologic diagnostics of salivary tumors considerably. Immunocytochemical examination must be used to reduce the errors, it enables to reveal neoplastic cells at early stages of malignization. High proliferative activity of tumor cells is one of their biological peculiarities. Accuracy in differential diagnostics between benign and malignant tumors is improved through determination of mitotic index combined with a fine needle aspiration puncture.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>опухоли слюнных желез</kwd>
    <kwd>аспирационная пункция тонкой иглой</kwd>
    <kwd>пролиферативный индекс</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>salivary tumors</kwd>
    <kwd>fine needle aspiration biopsy</kwd>
    <kwd>proliferative index</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">МайбородаА.А. Молекулярно-генетические особенности онкогенеза: пособие для врачей. - Ир-кутск: ИГМУ, 2015 - 54с. MayborodaAA (2015)</mixed-citation>
     <mixed-citation xml:lang="en">Molecular and genetic pecu-liarities of oncogenesis: manual for physicians [Molekul-yarno-geneticheskie osobennosti onkogeneza: posobie dlya vrachey], 54.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">ПанфиловаМ.М. Цитологическое исследование в диагностике опухолей и опухолевидных заболева-ний в околоушной слюнной железе //Вопр. клин. мед. - Душанбе, 1970. - Вып.1. - С.178-179.</mixed-citation>
     <mixed-citation xml:lang="en">PanfilovaMM (1970). Cytologic examination in the diagnostics of tumors and carsinomatous pathology of parotid salivary gland [Tsitologicheskoe issledovanie v diagnostike opukholey i opukholevidnykh zabolevaniy v okoloushnoy slyunnoy zheleze]. Voprosy klinicheskoy meditsiny, (1), 178-179.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">ПачесА.И. Опухоли головы и шеи; 4-е изд. - М.: Медицина, 2000. - 480с</mixed-citation>
     <mixed-citation xml:lang="en">PachesAI (2000). Neck and head tumors [Opukholi golovy i shei], 480.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">ТарасенкоС.В., СмысленоваМ.В., ШипковаТ.П., РудневА.И. Дифференциальная диагностика, вклю-чающая сравнение морфологических и сонографи-ческих особенностей новообразований больших слюнных желез //Российский стоматологический журнал. - 2014. - No3. - С.39-41.</mixed-citation>
     <mixed-citation xml:lang="en">TarasenkoSV, SmyslenovaMV, ShipkovaTP, RudnevAI(2014). Differential diagnosis, including a comparison of morphological and sonographic features of the tumors of the major salivary glands. [Differentsial’naya diagnostika, vkly-uchayushchaya sravnenie morfologicheskikh i sonografich-eskikh osobennostey novoobrazovaniy bol’shikh slyunnykh zhelez]. Rossiyskiy stomatologicheskiy zhurnal, (3), 39-41.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">ФедяевИ.М., БайриковИ.М., БеловаЛ.П., Шува-ловаТ.В. Злокачественные опухоли челюстно-лице-вой области. - М.: Медицинская книга; Н.Новгород: Изд-во НГМА, 2000. - 160с.</mixed-citation>
     <mixed-citation xml:lang="en">FedyayevIM, BayrikovIM, BelovaLP, ShuvalovaTV (2000). Malignant maxillofacial tumors. [Zlokachestven-nye opukholi chelyustno-litsevoy oblasti], 160.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru"></mixed-citation>
     <mixed-citation xml:lang="en">AlvesFA, PiresFR, deAlmediaOP (2004). PCNA, Ki-67 and p53 expressions in submandibular salivary gland tumors. Int. J. Oral-Maxilofac. Surg., 33(6), 593-597.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru"></mixed-citation>
     <mixed-citation xml:lang="en">HoriiA, YoshidaJ, SakaiM (1998). Flow cytometric analysis of DNA content and Ki-67-positive fractions in diagnosis of salivary gland tumors. Eur. Arch. Otorhino-laryngol., 255(5), 265-268.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
