ORGANOPHOSPHOROUS NEUROTOXINS
VAC 02.00.15 Кинетика и катализ VAC 03.01.2002 Биофизика VAC 03.01.2004 Биохимия VAC 03.01.2006 Биотехнология (в том числе бионанотехнологии) UDK 51 Математика UDK 54 Химия. Кристаллография. Минералогия. Минераловедение UDK 57 Биологические науки UDK 61 Медицина. Охрана здоровья UDK 63 Сельское хозяйство. Лесное хозяйство. Охота. Рыбное хозяйство UDK 66 Химическая технология. Химическая промышленность. Родственные отрасли GRNTI 31.21 Органическая химия GRNTI 31.23 Биоорганическая химия. Природные органические соединения и их синтетические аналоги GRNTI 31.27 Биологическая химия GRNTI 34.17 Биофизика GRNTI 34.35 Экология GRNTI 34.47 Токсикология OKSO 04.03.01 Химия OKSO 04.07.01 Химические науки OKSO 06.07.01 Биологические науки OKSO 18.03.01 Химическая технология BBK 24 Химические науки BBK 242 Органическая химия BBK 28 Биологические науки BBK 528 Фармакология. Фармация. Токсикология TBK 62 Химические науки TBK 622 Органическая химия TBK 6224 Биоорганическая химия TBK 6242 Природные полимеры TBK 626 Физическая химия. Химическая физика TBK 636 Экология TBK 64 Биологические науки TBK 6412 Молекулярная биология. Общая морфология, биофизика, биохимия, физиология TBK 6444 Биофизика, биохимия, физиология и экология растений BISAC SCI010000 Biotechnology BISAC SCI013040 Chemistry / Organic BISAC SCI013090 Chemistry / Toxicology BISAC SCI026000 Environmental Science (see also Chemistry / Environmental) BISAC SCI007000 Life Sciences / Biochemistry BISAC SCI009000 Life Sciences / Biophysics BISAC SCI020000 Life Sciences / Ecology
Abstract and keywords
Abstract (English):
The collective monograph is devoted to discussing the history of creation, studying the properties, neutralizing and using organophosphorus neurotoxins, which include chemical warfare agents, agricultural crop protection chemical agents (herbicides and insecticides) and medicines. The monograph summarizes the results of current scientific research and new prospects for the development of this field of knowledge in the 21st century, including the use of modern physicochemical methods for experimental study and theoretical analysis of biocatalysis and its mechanisms based on molecular modeling with supercomputer power. The book is intended for specialists who are interested in the current state of research in the field of organophosphorus neurotoxins. The monograph will be useful for students, graduate students, researchers specializing in the field of physical chemistry, physicochemical biology, chemical enzymology, toxicology, biochemistry, molecular biology and genetics, biotechnology, nanotechnology and biomedicine.

Keywords:
organophosphorus compounds, kinetic model, dynamics of the process, the human brain, inhibition of acetylcholinesterase, acetylcholine, neuromuscular contraction, cholinergic synapse, synaptic cleft, degradation, immobilized enzymes, environmental safety, hydrolases, oxidoreductases, C-P-bound, cholinesterase, phosphatase, organophosphate hydrolase, catalysis mechanism, active center, metal ions, computer modeling, self-detoxification, composite protective materials, microbial biodegradation
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