22594nam#a2201561#i#450# 1825 20240425122525.4 20200211d2020####ek#y0engy0150####ca 978-5-369-02026-5 RUS xxu Biotechnology. SCI010000 Chemistry / Organic. SCI013040 Chemistry / Toxicology. SCI013090 Environmental Science (see also Chemistry / Environmental). SCI026000 Life Sciences / Biochemistry. SCI007000 Life Sciences / Biophysics. SCI009000 Life Sciences / Ecology. SCI020000 Математика. 51 Химия. Кристаллография. Минералогия. Минераловедение. 54 Биологические науки. 57 Медицина. Охрана здоровья. 61 Сельское хозяйство. Лесное хозяйство. Охота. Рыбное хозяйство. 63 Химическая технология. Химическая промышленность. Родственные отрасли. 66 Химические науки. 24 bbk Органическая химия. 242 bbk Биологические науки. 28 bbk Фармакология. Фармация. 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Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Efremenko, Elena Nikolaevna Lomonosov Moscow State University Inozemcev, Valeriy Alexandrovich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Komissarenko, Sergey Anatol'evich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Kurochkin, Il'ya Nikolaevich Emanuel Institute of Biochemical Physics Russian Academy of Sciences Leontievsky, Alexey Arkad'evich G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Lushchekina, Sofya Vladimirovna Emanuel Institute of Biochemical Physics Russian Academy of Sciences Lyagin, Il'ya Vladimirovich Lomonosov Moscow State University Maslova, Olga Vasil'evna Lomonosov Moscow State University Masson, Patrick Ivon Moris Kazan Federal University Mahaeva, Galina Fayvelevna Institute of Physiologically Active Substances Russian Academy of Sciences Mahlis, Tat'yana Abramovna Lomonosov Moscow State University Medveckiy, Igor Viktorovich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Moralev, Sergey Nikolaevich Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS Nelga, Igor Alikovich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Nechaeva, Nataliya Leonidovna Emanuel Institute of Biochemical Physics Russian Academy of Sciences Novichkova, Dana Alexandrovna Emanuel Institute of Biochemical Physics Russian Academy of Sciences Nemuchin, Alexander Vladimirivich Emanuel Institute of Biochemical Physics Russian Academy of Sciences Rozengart, Evgeniy Viktorovich Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS Sviridov, Alexey Vladimirivich G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Sen'ko, Ol'ga Vital'evna Lomonosov Moscow State University Stepanov, Nikolay Alekseevich Lomonosov Moscow State University Tretyakov, Sergey Vadimovich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Frolov, George Alexandrovich Institute of Steel and Alloys Tsybenova, Svetlana Batozhargalovna Emanuel Institute of Biochemical Physics Russian Academy of Sciences Sherstyuk, Artem Valer'evich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Shushkova, Tatyana Valentinovna G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Epiktetov, Dmitriy Olegovich G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences ORGANOPHOSPHORUS NEUROTOXINS Monography Moscow Publishing Center RIOR 2020 380 p. The collective monograph is devoted to discussing the history of creation, studying the properties, neutralizing and using organophosphorus neurotoxins, which include chemical warfare agents, agricultural crop protection chemical agents (herbicides and insecticides) and medicines. The monograph summarizes the results of current scientific research and new prospects for the development of this field of knowledge in the 21st century, including the use of modern physicochemical methods for experimental study and theoretical analysis of biocatalysis and its mechanisms based on molecular modeling with supercomputer power. The book is intended for specialists who are interested in the current state of research in the field of organophosphorus neurotoxins. The monograph will be useful for students, graduate students, researchers specializing in the field of physical chemistry, physicochemical biology, chemical enzymology, toxicology, biochemistry, molecular biology and genetics, biotechnology, nanotechnology and biomedicine. organophosphorus compounds, kinetic model, dynamics of the process, the human brain, inhibition of acetylcholinesterase, acetylcholine, neuromuscular contraction, cholinergic synapse, synaptic cleft, degradation, immobilized enzymes, environmental safety, hydrolases, oxidoreductases, C-P-bound, cholinesterase, phosphatase, organophosphate hydrolase, catalysis mechanism, active center, metal ions, computer modeling, self-detoxification, composite protective materials, microbial biodegradation 10.29039/02026-5 Aslanli A.G., Stepanov N.A., Senko O.V., Maslova O.V., Lyagin I.V., Efremenko E.N. The hexahistidine containing organophosphorus hydrolase enzyme and bacterial cellulose based functional materials. 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