Problems of the treatment of comorbid patients in routine clinical practice remain highly relevant. One of the most common combinations – coronary heart disease and diabetes mellitus type 2. In this article, the authors present their own experience of studying the effects of infusion of the drug "Reamberin" at the stage of percutaneous coronary intervention on the dynamics of indicators of lipid peroxidation in patients with myocardial infarction with diabetes mellitus type 2. This study consists of the examination and treatment analysis of 54 patients, men aged 64,3 ± 6,8 years old with coronary heart disease and clinical manifestations of acute myocardial infarction and concomitant diabetes mellitus type 2. The percutaneous intervention was made of this group of patients. To determine the normal values of the studied parameters, the examination of 34 patients with coronary heart disease without exacerbation (men aged 62,5 ± 4,2 years) with concomitant diabetes mellitus type 2, was carried out. It is found that the development of acute myocardial infarction in patients with diabetes type 2 is accompanied by activation of processes of lipid peroxidation and antioxidant system of blood with a predominance of lipid peroxidation. It is proved that the use of succinic acid drug "Reamberin" at the stage of percutaneous coronary intervention in these patients contributes to the decrease in the intensity of free radical processes and increases the activity of enzymatic antioxidants.
acute myocardial infarction, diabetes mellitus, lipid metabolism
1. Bilenko M.V. Ishemicheskie i reperfuzionnye povrezhdeniya organov: molekulyarnye mekhanizmy,puti preduprezhdeniya i lecheniya. M.: Meditsina, 1989. 367 s.
2. Gavrilov V.B., Gavrilova A.R., Mazhul´ L.M. Analiz metodov opredeleniya produktov perekisnogo okisleniya lipidov v syvorotke krovi po testu s tiobarbiturovoy kislotoy. Vopr. med. khimii. 1987. 33 (1). S. 118-122.
3. Gerasimets I.M., Rudykh V.I., Blinova N.G. Vliyanie riboksina i korinfara na techenie sindroma peroksidatsii pri ostrom infarkte miokarda. Zdorov´e. 1990. №22. S. 63-68.
4. Davydov B.V., Poluminskov V.Yu., Golikov P.P., Golikov A.P. Integral´naya otsenka balansa perekisnogo okisleniya lipidov i antioksidantnoy sistemy. Klinicheskaya laboratornaya diagnostika. Tez. Dokladov 4 Vsesoyuznogo S´´ezda spetsialistov po laboratornoy diagnostike. Moskva, 1991. S. 48-49.
5. Zilov V.G., Khadartsev A.A., Es´kov V.M., Vinokurov B.L., Morozov V.N., Kidalov V.N., Filatova O.E., Gontarev S.N., Khadartseva K.A., Tsogoev A.S., Naumova E.M., Kryukova S.V., Mitrofanov I.V., Valentinov B.G., Sedova O.A. Vosstanovitel´naya meditsina: Monografiya / Pod red. A.A. Khadartseva, S.N. Gontareva, V.M. Es´kova. Tula: Izd-vo TulGU - Belgorod: ZAO «Belgorodskaya oblastnaya tipografiya», 2010. T. I. 298 s.
6. Kogan A.Kh. Fagotsitzavisimye kislorodnye svobodnoradikal´nye mekhanizmy agressii v patogeneze vnutrennikh bolezney. Vestnik RAMN. 1999. №2. S. 3-10.
7. Kogan V.E., Orlov V.N., Prilipko L.L. Problema analiza endogennykh produktov perekisnogo okisleniya lipidov. Biofizika. 1986. №18. S. 56-57.
8. Kornienko E.A., Oynotkinova O.Sh., Baranov A.P., Goncharova E.I., Ivanov D.V. Sovremennye vzglyady na etiopato- genez infarkta miokarda pri sakharnom diabete 2 tipa i metody lecheniya (obzor literatury). Vestnik novykh meditsinskikh tekhnologiy. Elektronnoe izdanie. 2015. №2. Publikatsiya 3-8. URL: http://www.medtsu.tula.ru/VNMT/ Bulletin/E2015-2/5198.pdf (data obrashcheniya: 30.06.2015). DOI:10.12737/ 11912.
9. Slobozhninova E.V. Otsenka effektivnosti preparatov yantarnoy kisloty v kompleksnoy terapii nestabil´noy stenokardii i infarkta miokarda bez zubtsa Q.. Avtoref. diss. kand. med. nauk. Tomsk, 2004. 24 s.
10. Duggan D.E. Spectorofluorometric determination of tocopherols. Arhi. Biochem. Biophis. 1959. №84. P. 1116-1122.
11. Ravin H.A. An improved colorimetric enzymatic assay of ceruloplasmin. J. Lab. Med. 1961. 58. P. 161-168.
