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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Clinical Medicine and Pharmacology</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Clinical Medicine and Pharmacology</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Клиническая медицина и фармакология</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2409-3750</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">93305</article-id>
   <article-id pub-id-type="doi">10.12737/2409-3750-2025-10-3-22-25</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>В помощь практикующему врачу</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>To help practitioner</subject>
    </subj-group>
    <subj-group>
     <subject>В помощь практикующему врачу</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">BEHCETS DISEASE IN THE PRACTICE OF AN INTERNAL DOCTOR</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>БОЛЕЗНЬ БЕХЧЕТА  В ПРАКТИКЕ ВРАЧА-ИНТЕРНИСТА</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Прохоров</surname>
       <given-names>П. Ю.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Prohorov</surname>
       <given-names>P. Yu.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Тульский государственный университет</institution>
    </aff>
    <aff>
     <institution xml:lang="en">Tula State University</institution>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2025-01-09T16:19:36+03:00">
    <day>09</day>
    <month>01</month>
    <year>2025</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2025-01-09T16:19:36+03:00">
    <day>09</day>
    <month>01</month>
    <year>2025</year>
   </pub-date>
   <volume>10</volume>
   <issue>3</issue>
   <fpage>22</fpage>
   <lpage>25</lpage>
   <history>
    <date date-type="received" iso-8601-date="2025-01-09T00:00:00+03:00">
     <day>09</day>
     <month>01</month>
     <year>2025</year>
    </date>
   </history>
   <self-uri xlink:href="https://naukaru.ru/en/nauka/article/93305/view">https://naukaru.ru/en/nauka/article/93305/view</self-uri>
   <abstract xml:lang="ru">
    <p>Болезнь Бехчета – системный васкулит неизвестной этиологии,  ряд  клинических проявлений которого соотносят с иммунным ответом, опосредованным Т-клетками. В связи с полисиндромностью при диагностике и лечении заболевания необходимо  мультидисциплинарное взаимодействие врачей в многопрофильной команде для обеспечения ранней диагностики и наибольшей эффективности терапии.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Behcet's disease is a systemic vasculitis of unknown etiology, a number of clinical manifestations of which are associated with the immune response mediated by T cells. Due to the polysyndromic nature of the disease, multidisciplinary interaction of doctors in a multidisciplinary team is necessary in the diagnosis and treatment of the disease to ensure early diagnosis and the greatest effectiveness of therapy.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>болезнь Бехчета</kwd>
    <kwd>васкулит</kwd>
    <kwd>язвы</kwd>
    <kwd>Т-клетки</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>Behcet's disease</kwd>
    <kwd>vasculitis</kwd>
    <kwd>ulcers</kwd>
    <kwd>T cells</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Yazici Y, Hatemi G, Bodaghi B, et al. Behçet syndrome. Nature Reviews Disease Primers. 2021; 7(1):1–14.</mixed-citation>
     <mixed-citation xml:lang="en">Yazici Y, Hatemi G, Bodaghi B, et al. Behçet syndrome. Nature Reviews Disease Primers. 2021; 7(1):1–14.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Lavalle S, Caruso S, Foti R, Gagliano C, Cocuzza S, La Via L, Parisi FM, Calvo-Henriquez C, Maniaci A. Behçet's Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review. Medicina (Kaunas). 2024 Mar 29;60(4):562.</mixed-citation>
     <mixed-citation xml:lang="en">Lavalle S, Caruso S, Foti R, Gagliano C, Cocuzza S, La Via L, Parisi FM, Calvo-Henriquez C, Maniaci A. Behçet's Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review. Medicina (Kaunas). 2024 Mar 29;60(4):562.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Манто И.А., Шигина Е.А. Болезнь Бехчета: история про то, как одна редкая болезнь замаскировалась под другую редкую болезнь. Российский журнал персонализированной медицины. 2024;4(3):276-281. DOI: 10.18705/2782-3806-2024-4-3- 276-281. EDN: HWYFWY</mixed-citation>
     <mixed-citation xml:lang="en">Manto I.A., Shigina E.A. Bolezn' Behcheta: istoriya pro to, kak odna redkaya bolezn' zamaskirovalas' pod druguyu redkuyu bolezn'. Rossiyskiy zhurnal personalizirovannoy mediciny. 2024;4(3):276-281. DOI: 10.18705/2782-3806-2024-4-3- 276-281. EDN: HWYFWY</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Алекберова З.С., Лисицына Т.А., Голоева Р.Г., Давыдова Г.А. Болезнь Бехчета: клинико-гендерные ассоциации // Современная ревматология. 2019. Т. 13, № 2. С. 84-89.</mixed-citation>
     <mixed-citation xml:lang="en">Alekberova Z.S., Lisicyna T.A., Goloeva R.G., Davydova G.A. Bolezn' Behcheta: kliniko-gendernye associacii // Sovremennaya revmatologiya. 2019. T. 13, № 2. S. 84-89.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Arida, A.; Saadoun, D.; Sfikakis, P.P. IL-6 blockade for Behçet’s disease: Review on 31 anti-TNF naive and 45 anti-TNF experienced patients. Clin. Exp. Rheumatol. 2022, 40, 1575–1583</mixed-citation>
     <mixed-citation xml:lang="en">Arida, A.; Saadoun, D.; Sfikakis, P.P. IL-6 blockade for Behçet’s disease: Review on 31 anti-TNF naive and 45 anti-TNF experienced patients. Clin. Exp. Rheumatol. 2022, 40, 1575–1583</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Bodis, G.; Toth, V.; Schwarting, A. Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases. Rheumatol. Ther. 2018, 5, 5–20</mixed-citation>
     <mixed-citation xml:lang="en">Bodis, G.; Toth, V.; Schwarting, A. Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases. Rheumatol. Ther. 2018, 5, 5–20</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Hatemi, G.; Uçar, D.; Uygunoğlu, U.; Yazici, H.; Yazici, Y. Behçet Syndrome. Rheum. Dis. Clin. N. Am. 2023, 49, 585–602.</mixed-citation>
     <mixed-citation xml:lang="en">Hatemi, G.; Uçar, D.; Uygunoğlu, U.; Yazici, H.; Yazici, Y. Behçet Syndrome. Rheum. Dis. Clin. N. Am. 2023, 49, 585–602.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">International Team for the Revision of the International Criteria for Behçet’s Disease (ITR-ICBD); Davatchi, F.; Assaad-Khalil, S.; Calamia, K.T.; Crook, J.E.; Sadeghi-Abdollahi, B.; Schirmer, M.; Tzellos, T.; Zouboulis, C.C.; Akhlagi, M.; et al. The International Criteria for Behçet’s Disease (ICBD): A collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J. Eur. Acad. Dermatol. Venereol. 2014, 28, 338–347.</mixed-citation>
     <mixed-citation xml:lang="en">International Team for the Revision of the International Criteria for Behçet’s Disease (ITR-ICBD); Davatchi, F.; Assaad-Khalil, S.; Calamia, K.T.; Crook, J.E.; Sadeghi-Abdollahi, B.; Schirmer, M.; Tzellos, T.; Zouboulis, C.C.; Akhlagi, M.; et al. The International Criteria for Behçet’s Disease (ICBD): A collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J. Eur. Acad. Dermatol. Venereol. 2014, 28, 338–347.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Лисицына Т.А., Алекберова З.С., Голоева Р.Г., Давыдова Г.А. Болезнь Бехчета: клинические проявления, современные принципы диагностики и терапии // Научно-практическая ревматология. 2019. Т.57, № 5. C. 553-563</mixed-citation>
     <mixed-citation xml:lang="en">Lisicyna T.A., Alekberova Z.S., Goloeva R.G., Davydova G.A. Bolezn' Behcheta: klinicheskie proyavleniya, sovremennye principy diagnostiki i terapii // Nauchno-prakticheskaya revmatologiya. 2019. T.57, № 5. C. 553-563</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Leccese, P.; Ozguler, Y.; Christensen, R.; Esatoglu, S.N.; Bang, D.; Bodaghi, B.; Celik, A.F.; Fortune, F.; Gaudric, J.; Gül, A.; et al. Management of skin, mucosa and joint involvement of Behçet’s syndrome: A systematic review for update of the EULAR recommendations for the management of Behçet’s syndrome. Semin. Arthritis. Rheum. 2019, 48, 752–762</mixed-citation>
     <mixed-citation xml:lang="en">Leccese, P.; Ozguler, Y.; Christensen, R.; Esatoglu, S.N.; Bang, D.; Bodaghi, B.; Celik, A.F.; Fortune, F.; Gaudric, J.; Gül, A.; et al. Management of skin, mucosa and joint involvement of Behçet’s syndrome: A systematic review for update of the EULAR recommendations for the management of Behçet’s syndrome. Semin. Arthritis. Rheum. 2019, 48, 752–762</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Пивень В.Д., Краснов В.С., Ляшок П.А., Неофидов Н.А., Бубнова Е.В., Тотолян Н.А. Болезнь Бехчета с неврологическими проявлениями. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019;119(10):67-73. https://doi.org/10.17116/jnevro201911910167</mixed-citation>
     <mixed-citation xml:lang="en">Piven' V.D., Krasnov V.S., Lyashok P.A., Neofidov N.A., Bubnova E.V., Totolyan N.A. Bolezn' Behcheta s nevrologicheskimi proyavleniyami. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2019;119(10):67-73. https://doi.org/10.17116/jnevro201911910167</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Saadoun, D. Behçet’s disease: The French recommendations. Rev. Med. Interne 2020, 41, 437–439</mixed-citation>
     <mixed-citation xml:lang="en">Saadoun, D. Behçet’s disease: The French recommendations. Rev. Med. Interne 2020, 41, 437–439</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kidd, D.P. Neurological involvement by Behçet’s syndrome: Clinical features, diagnosis, treatment and outcome. Pract. Neurol. 2023, 23, 386–400.</mixed-citation>
     <mixed-citation xml:lang="en">Kidd, D.P. Neurological involvement by Behçet’s syndrome: Clinical features, diagnosis, treatment and outcome. Pract. Neurol. 2023, 23, 386–400.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Merlino L, Del Prete F, Lobozzo B, Priori R, Piccioni MG. Behcet's disease and pregnancy: a systematic review. Minerva Ginecol. 2020 Oct;72(5):332-338. doi: 10.23736/S0026-4784.20.04564-5.</mixed-citation>
     <mixed-citation xml:lang="en">Merlino L, Del Prete F, Lobozzo B, Priori R, Piccioni MG. Behcet's disease and pregnancy: a systematic review. Minerva Ginecol. 2020 Oct;72(5):332-338. doi: 10.23736/S0026-4784.20.04564-5.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Barros T, Braga A, Marinho A, Braga J. Behçet's Disease and Pregnancy: A Retrospective Case-control Study. Yale J Biol Med. 2021 Dec 29;94(4):585-592.</mixed-citation>
     <mixed-citation xml:lang="en">Barros T, Braga A, Marinho A, Braga J. Behçet's Disease and Pregnancy: A Retrospective Case-control Study. Yale J Biol Med. 2021 Dec 29;94(4):585-592.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
