Tula, Tula, Russian Federation
UDK 61 Медицина. Охрана здоровья
The article discusses the prerequisites for the occurrence of bradyarrhythmias in young patients, in the absence of organic heart pathology. The focus of the review is on the rarest causes of conduction disorders. A clinical case of drug-induced 2nd degree atrioventricular block during antiretroviral therapy is illustrated. The role of increasing the level of patient confidence to verify the nature of a given arrhythmia is noted, which directly affects the choice of treatment tactics and further management of the patient.
cardiotoxicity, bradyarrhythmia, atrioventricular block
1. Bradiaritmii i narusheniya provodimosti. Rossiyskoe kardiologicheskoe obschestvo. Klinicheskie rekomendacii 2020. Rossiyskiy kardiologicheskiy zhurnal. 2021;26(4):4448. doihttps://doi.org/10.15829/1560-4071-2021-4448.
2. Sidhu S, Marine JE. Evaluating and managing bradycardia. Trends Cardiovasc Med. 2020 Jul;30(5):265-272. doi:https://doi.org/10.1016/j.tcm.2019.07.001. Epub 2019 Jul 9. PMID: 31311698.
3. Belyalov F.I. B43 Aritmii serdca: monografiya; izd. 5, pererab. i dop. – Irkutsk: RIO IMAPO, 2011. 333 s. ISBN 978–5–89786–090–6
4. Resdal Dyssekilde J, Frederiksen TC, Christiansen MK, Hasle Sørensen R, Pedersen LN, Loof Moller P, Christensen LS, Larsen JM, Thomsen KK, Lindhardt TB, Böttcher M, Molsted S, Havndrup O, Fischer T, Møller DS, Henriksen FL, Johansen JB, Nielsen JC, Bundgaard H, Nygaard M, Jensen HK. Diagnostic Yield of Genetic Testing in Young Patients With Atrioventricular Block of Unknown Cause. J Am Heart Assoc. 2022 May 3;11(9):e025643. doi:https://doi.org/10.1161/JAHA.121.025643. Epub 2022 Apr 26. PMID: 35470684; PMCID: PMC9238593.
5. Auricchio A, Demarchi A, Özkartal T, Campanale D, Caputo ML, di Valentino M, Menafoglio A, Regoli F, Facchini M, Del Bufalo A, Foglia P, Ferrari N, Bomio F, Medeiros-Domingo A, Moccetti T, Pedrazzini GB, Klersy C, Conte G. Role of genetic testing in young patients with idiopathic atrioventricular conduction disease. Europace. 2023 Feb 16;25(2):643-650. doi:https://doi.org/10.1093/europace/euac196. PMID: 36352534; PMCID: PMC9934995.
6. Kushakovskiy, M. S. Aritmii serdca (Rasstroystva serdechnogo ritma i narusheniya provodimosti. Prichiny, mehanizmy, elektrokardiograficheskaya i elektrofiziologicheskaya diagnostika, klinika, lechenie) : Rukovodstvo dlya vrachey / M. S. Kushakovskiy, Yu. N. Grishkin. – Sankt-Peterburg : Foliant, 2014. – 720 s. – ISBN 978-5-93929-245-0. – EDN YSMUDH.
7. Alboni P, Holz A, Brignole M. Vagally mediated atrioventricular block: pathophysiology and diagnosis. Heart. 2013 Jul;99(13):904-8. doi:https://doi.org/10.1136/heartjnl-2012-303220. Epub 2013 Jan 2. PMID: 23286970.
8. Michele Brignole, Angel Moya, Frederik J. De Lange, Jean-Claude Deharo, Perry M. Elliott, Alessandra Fanciulli, Artur Fedorowski, Raffaello Furlan, Rose Anne Kenny, Alfonso Martın, Vincent Probst, Matthew J. Reed, Ciara P. Rice, Richard Sutton, Andrea Ungar, J. Gert Van Dijk Rekomendacii EOK po diagnostike i lecheniyu sinkopal'nyh sostoyaniy 2018 // RKZh. 2019. №7.
9. Kusumoto FM, Schoenfeld MH, Barrett C, Edgerton JR, Ellenbogen KA, Gold MR, Goldschlager NF, Hamilton RM, Joglar JA, Kim RJ, Lee R, Marine JE, McLeod CJ, Oken KR, Patton KK, Pellegrini CN, Selzman KA, Thompson A, Varosy PD. 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2019 Aug 20;140(8):e382-e482. doi:https://doi.org/10.1161/CIR.0000000000000628. Epub 2018 Nov 6. Erratum in: Circulation. 2019 Aug 20;140(8):e506-e508. PMID: 30586772.
10. Kalyuta T.Yu., Kiselev A.R., Bazarbaeva A.H. Kardiotoksichnost' lekarstvennyh preparatov: vozmozhnosti profilaktiki i korrekcii//Saratovskiy nauchno-medicinskiy zhurnal 2020. t.16. №3, s.736-743
11. Gvela Yu.N., Kinyasheva N.B. Sluchay ranney diagnostiki toksicheskoy kardiomiopatii u pacientki, poluchayuschey tamoksifen po povodu raka molochnoy zhelezy//Klinicheskaya medicina i farmakologiya 2021. T.7 №3, s.
12. Siluyanova I.V., Yakovlev V.V. «Vrach glazami pacientov: rezul'taty sociologicheskih oprosov». Glavvrach. 2009.-N 3.-S. 87–93.
13. Amyaga N.V. Samoraskrytie i samopred'yavlenie lichnosti v obschenii- M.: AN SSSR, INION, 1991, s.37-74
14. Dmitrieva E. V. Doverie k vrachu kak uslovie ustanovleniya social'no-psihologicheskogo otnosheniya i obscheniya mezhdu vrachom i pacientom // Vestnik LGU im. A.S. Pushkina. 2010.
15. Zudbinov, Yu.I. Azbuka EKG i boli v serdce [Tekst] / Yu.I. Zudbinov; SPb. : SPbLTA, 2008. – 198 s.
16. Fresse A, Viard D, Romani S, Gérard A, Lepelley M, Rocher F, Salem JE, Drici MD; French Network of Pharmacovigilance Centers. Spontaneous reported cardiotoxicity induced by lopinavir/ritonavir in COVID-19. An alleged past-resolved problem. Int J Cardiol. 2021 Feb 1;324:255-260. doi:https://doi.org/10.1016/j.ijcard.2020.10.028. Epub 2020 Oct 16. PMID: 33075384; PMCID: PMC7566676.
17. Santimaleeworagun W, Pattharachayakul S, Chusri S, Chayagul P. Atazanavir induced first degree atrioventricular block and ventricular tachycardia: a case report. J Med Assoc Thai. 2013 Apr;96(4):501-3. PMID: 23691707.
18. Lekarstvennyy spravochnik GEOTAR. Ritonavir-100, 2023g.
19. Yurin O.G., Efremova O.S. Evropeyskie i amerikanskie rekomendacii po lecheniyu VICh-infekcii // MS. 2017. №4.
20. https://grls.pharm-portal.ru/grls/f92726ff-9689-46b7-b151-a43242fc5274#instructions