Clinical Medicine and Pharmacology Clinical Medicine and Pharmacology Клиническая медицина и фармакология 2409-3750 73888 10.12737/2409-3750-2024-9-4-2-7 Обзоры reviews Обзоры THE IMPORTANCE OF P16 GENE EXPRESSION AS A FACTOR OF TUMOR BLAST CELL TRANSFORMATION (literature review) ЗНАЧЕНИЕ ЭКСПРЕССИИ ГЕНА P16, КАК ФАКТОРА ОПУХОЛЕВОЙ БЛАСТТРАНСФОРМАЦИИ КЛЕТОК (обзор литературы) Субботина Татьяна Игоревна Subbotina Tat'yana Igorevna Гусейнов Ариф Зиядович Guseynov Arif Ziyadovich Гольцова Е. О. Gol'cova E. O. Чижова В. В. Chizhova V. V. Руднева А. А. Rudneva A. A. Тульский государственный университет Россия Тульский государственный университет Russian Federation Тульский государственный университет Россия Тульский государственный университет Russian Federation Тульский государственный университет Tula State University Рязанский государственный медицинский университет им. акад. И.П.Павлова Ryazan State Ivan Petrovich Pavlov Medical University 30 01 2024 30 01 2024 9 4 2 7 30 01 2024 https://naukaru.ru/en/nauka/article/73888/view

Для более достоверного предсказания поведения опухолей и индивидуализации лечебного подхода необходимо совершенствование новых методов ранней диагностики предраковых состояний. В статье дан обзор современного представления о механизмах экспрессии гена р16, как фактора опухолевого роста. Приведены данные об актуальности изучения патогенеза опухолевой бласттрансформации при инвазивной карциноме молочной железы. Эти опухоли требуют сопряженной междисциплинарной работы высококвалифицированных специалистов и ультрасовременных технологий для достижения положительного результата. Описана связь формирования злокачественных опухолей молочной железы с вирусом папилломы человека. Целью данного исследования была рецензия футурологический значимости иммуногистохимического анализа р16 у пациенток различной возрастной группы с распространенным раком шейки матки и карциномы молочной железы. Показана возможность использования детерминации экспрессии р16 в качестве прогностического маркера рака молочной железы, а также результаты исследования экспрессии р16 и р53 при тройном негативном раке молочной железы. Проанализированы данные, отражающие зависимость эффективности супрессорной функции от локализации экспрессии р16 при плоскоклеточном раке шейки матки. Указана зависимость экспрессии p16INK4a от тяжести злокачественного поражения шейки матки и рассмотрено влияние режима химиотерапии на экспрессию p16. Изучая и применяя сведения об онтогенетической изменчивости гена р16, есть возможность многократно повысить точность прогноза клинического и патоморфологического течения рака любой природы возникновения и, подобрать адекватную терапию: генную, химиотерапию, лучевую терапию.

For a more accurate prediction of tumor behavior and individualization of treatment approach, it is necessary to improve new methods of early diagnosis of precancerous conditions. The article provides an overview of the modern understanding of the mechanisms of gene p16 expression as a factor in tumor growth. Data on the relevance of studying the pathogenesis of tumor blast transformation in invasive breast cancer are presented. These tumors require the combined interdisciplinary work of highly qualified specialists and ultra-modern technologies to achieve a positive result. The link between the formation of malignant breast tumors and human papillomavirus is described. The purpose of this study was to review the futuristically significant immunohistochemical analysis of p16 in patients of different age groups with common cervical cancer and breast cancer. The possibility of using the determination of p16 expression as a prognostic marker for breast cancer is shown, as well as the results of studying the expression of p16 and p53 in triple-negative breast cancer. The data reflecting the dependence of the suppressor function efficiency on the localization of p16 expression in squamous cell carcinoma of the cervix are analyzed. The dependence of p16INK4a expression on the severity of malignant cervical lesions is indicated, and the effect of chemotherapy on p16 expression is considered. By studying and applying information on the ontogenetic variability of the p16 gene, it is possible to significantly increase the accuracy of predicting the clinical and pathomorphological course of cancer of any nature of occurrence and to select adequate therapy: gene, chemotherapy, radiation therapy.

 ген р16 опухолевая бласттрансформация карцинома молочной железы вирус папилломы человека рак шейки матки. p16 gene tumor blast transformation breast carcinoma human papillomavirus cervical cancer

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