The effectiveness of isolated retrograde endoscopic interventions and combined manipulations by the method «Randevu», also surgical operations for the purpose of elimination of choledocholithiasis, complicated by mechanical jaundice was defined on a large clinical material. It was identified a significant decline in hyperbilirubinemia in all used methods of treatment. Liver enzymes alanineaminotransferase and aspartate aminotransferase significantly reduced in the application of minimally invasive retrograde endoscopic and combined manipulations by the method «Randevu». There was a significant decrease in the diameter of the common bile duct by ultrasound only at the use of combined interventions by the method «Randevu». There was the greatest number of complications at the use of surgical methods of treatment of choledocholithiasis, complicated by mechanical jaundice, reaching 20% of cases. The rate of complications at the use of minimally invasive retrograde resolution methods of choledocholithiasis averaged 3% of cases. Postoperative complications are not observed at the use of the combined manipulations by the method "Randevu". Based on the analysis of the above data, the author determines the best treatment outcomes in patients with concomitant minimally invasive operations on the method of «Randevu», manifested a significant decrease in indicators of bilirubi-nemia, hepatic enzymes, diameter of the common bile duct. Also, this two-step tactic can be recommended for the extreme severity of the patient´s state, complicated by obstructive jaundice.