In modern conditions, defined by most domestic and foreign researchers as the ‘new normal”, new approaches are being formed to ensure the scientific and technological development of economies at the macro, meso and micro levels. The rapid transformation of the main trends in the geopolitical and economic situation in the country, the change in the emphasis of the import substitution policy in the sectors of the national economy, have led to the complication of the tasks facing the domestic economy related to the need to form a new system of priorities for national and regional innovation policy. The authors of the article carried out work to identify global challenges, risks and potential threats of the agricultural development until 2030, as well as to form the prerequisites for the scientific and technological development of the market for scientific and technological initiatives (NTI) Foodnet. To understand the development of the NTI Foodnet market, the authors conducted a study of the prerequisites and reasons for the increased interest of foreign and domestic researchers in this article. In the study, the authors identified the factors for the creation and forming of the Foodnet market in the face of increased economic sanctions, geopolitical turbulence, and the growing problem of food security. The authors of the article made the assumption that this concept will solve the problems of import substitution of the agricultural industry of the regions of the Russian Federation through the introduction of new technologies and new principles for organizing the interaction of participants in the Foodnet market, which is open to the integration of new high technologies, through the introduction of new solutions based on digitalization and customization of agricultural products.