<!DOCTYPE article
PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20190208//EN"
       "JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.4" xml:lang="en">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Medical Radiology and radiation safety</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Medical Radiology and radiation safety</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Медицинская радиология и радиационная безопасность</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">1024-6177</issn>
   <issn publication-format="online">2618-9615</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">45278</article-id>
   <article-id pub-id-type="doi">10.12737/1024-6177-2021-66-3-76-81</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>В помощь практическому врачу</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>Medical practice issue</subject>
    </subj-group>
    <subj-group>
     <subject>В помощь практическому врачу</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">Successful Case of Treatment the Patient with Synchronous Rectal  and Sigmoid Cancers and Synchronous Lung Metastasis</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>СЛУЧАЙ УСПЕШНОГО ЛЕЧЕНИЯ ПАЦИЕНТА  С СИНХРОННЫМИ ОПУХОЛЯМИ ПРЯМОЙ И СИГМОВИДНОЙ КИШКИ  И СИНХРОННЫМИ МЕТАСТАЗАМИ В ЛЕГКИЕ</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Полыновский</surname>
       <given-names>А. В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Polynovskiy</surname>
       <given-names>A. V.</given-names>
      </name>
     </name-alternatives>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Кузьмичев</surname>
       <given-names>Д. В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Kuz'michev</surname>
       <given-names>D. V.</given-names>
      </name>
     </name-alternatives>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Мамедли</surname>
       <given-names>З. З.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Mamedli</surname>
       <given-names>Z. Z.</given-names>
      </name>
     </name-alternatives>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Ткачев</surname>
       <given-names>Сергей Иванович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Tkachev</surname>
       <given-names>Sergey Ivanovich</given-names>
      </name>
     </name-alternatives>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Черных</surname>
       <given-names>М. В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Chernich</surname>
       <given-names>M. V.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-5"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Сураева</surname>
       <given-names>Ю. Э.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Suraeva</surname>
       <given-names>Yu. E.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-6"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Мадьяров</surname>
       <given-names>Ж. М.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Madyarov</surname>
       <given-names>J. M.</given-names>
      </name>
     </name-alternatives>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-7"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Анискин</surname>
       <given-names>А. А.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Aniskin</surname>
       <given-names>A. A.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-8"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Колобанова</surname>
       <given-names>Е. С.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Kolobanova</surname>
       <given-names>E. S.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-9"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава России</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава России</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава России</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава России</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-5">
    <aff>
     <institution xml:lang="ru">Национальный медицнский исследовательский исследовательский центр онкологии им. Н.Н. Блохина  Минздрава РФ, Москва</institution>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia</institution>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-6">
    <aff>
     <institution xml:lang="ru">ОРЦ ПЭТ Технолоджи, Подольск, Московская обл.</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">PET-Technology, Podolsk, Moscow Region, Russia</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-7">
    <aff>
     <institution xml:lang="ru">Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава России</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-8">
    <aff>
     <institution xml:lang="ru">Национальный медицнский исследовательский исследовательский центр онкологии им. Н.Н. Блохина  Минздрава РФ, Москва</institution>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia</institution>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-9">
    <aff>
     <institution xml:lang="ru">Национальный медицнский исследовательский исследовательский центр онкологии им. Н.Н. Блохина  Минздрава РФ, Москва</institution>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia</institution>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <volume>66</volume>
   <issue>3</issue>
   <fpage>76</fpage>
   <lpage>81</lpage>
   <history>
    <date date-type="received" iso-8601-date="2021-07-20T00:00:00+03:00">
     <day>20</day>
     <month>07</month>
     <year>2021</year>
    </date>
   </history>
   <self-uri xlink:href="https://naukaru.ru/en/nauka/article/45278/view">https://naukaru.ru/en/nauka/article/45278/view</self-uri>
   <abstract xml:lang="ru">
    <p>Колоректальный рак (КРР) занимает лидирующие позиции по частоте заболеваемости и смертности во всем мире. Диссеминированный КРР при первичной диагностике составляет  от 15 до 35 %. Метастазы в легких  являются самым частым внебрюшным проявлением метастатического процесса. Доля больных, у которых выявлены изолированные метастазы в легких, составляет всего лишь от 2 до 7,4 %. Такие пациенты являются относительно редкими, и до настоящего времени нет четких рекомендаций по их лечебной тактике. Данное клиническое наблюдение описывает успешный случай применения предоперационной пролонгированной химиолучевой терапии на первичную опухоль и стереотаксическое облучение метастатических очагов в легких, с курсами лекарственной терапии, с дальнейшим оперативным вмешательством в радикальном объеме лапароскопическим доступом, у пациента с диссеминированным первично-множественным раком прямой кишки, синхронным раком сигмовидной кишки и 2 метастатическими очагами в обоих легких.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Colorectal cancers (CRC) takes the leading position in the incidence of morbidity and mortality worldwide. Metastatic CRC in the primary diagnosis ranges from 15 to 35 %. Lung metastasis are the most frequent extraperitoneal manifestation of the metastatic process. Such patients are relatively rare and there are no clear recommendations for their treatment tactics to date. This clinical case describes a successful strategy of using preoperative prolonged chemoradiotherapy on a primary tumor and stereotactic irradiation of lung metastasis, with courses of chemotherapy, with further radical laparoscopic operation, in a patient with disseminated primary multiple rectal cancer, synchronous sigmoid colon cancer and 2 metastatic focuses in both lungs.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>рак прямой кишки</kwd>
    <kwd>диссеминированный</kwd>
    <kwd>метастазы в легкие</kwd>
    <kwd>стереотаксическая лучевая терапия</kwd>
    <kwd>химиолучевая терапия</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>rectal cancer</kwd>
    <kwd>metastatic</kwd>
    <kwd>lung metastasis</kwd>
    <kwd>stereotactic body radiotherapy</kwd>
    <kwd>ablative radiation therapy</kwd>
    <kwd>chemoradiotherapy</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S. et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012; Eur J Cancer 2013;49(6):1374-403.</mixed-citation>
     <mixed-citation xml:lang="en">Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S. et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012; Eur J Cancer 2013;49(6):1374-403.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Goldberg RM. Advances in the treatment of metastatic colorectal cancer. Oncologist. 2005; 10 Suppl 3:40-8.</mixed-citation>
     <mixed-citation xml:lang="en">Goldberg RM. Advances in the treatment of metastatic colorectal cancer. Oncologist. 2005; 10 Suppl 3:40-8.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Zacharakis M, Xynos I.D, Lazaris A. et al. Predictors of survival in stage IV metastatic colorectal cancer. Anticancer Res. 2010;30(2):653-60.</mixed-citation>
     <mixed-citation xml:lang="en">Zacharakis M, Xynos I.D, Lazaris A. et al. Predictors of survival in stage IV metastatic colorectal cancer. Anticancer Res. 2010;30(2):653-60.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Manfredi S, Lepage C, Hatem C, Coatmeur O. et al. Epidemiology and management of liver metastases from colorectal cancer. Ann Surg. 2006;244(2):254-9.</mixed-citation>
     <mixed-citation xml:lang="en">Manfredi S, Lepage C, Hatem C, Coatmeur O. et al. Epidemiology and management of liver metastases from colorectal cancer. Ann Surg. 2006;244(2):254-9.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Nordholm-Carstensen A, Krarup PM, Jorgensen LN, Wille-Jorgensen PA, et al. On behalf of Danish colorectal Cancer group. Occurrence and survival of synchronous pulmonary metastases in colorectal cancer: a nationwide cohort study. Eur J Cancer. 2014; 50:447-56.</mixed-citation>
     <mixed-citation xml:lang="en">Nordholm-Carstensen A, Krarup PM, Jorgensen LN, Wille-Jorgensen PA, et al. On behalf of Danish colorectal Cancer group. Occurrence and survival of synchronous pulmonary metastases in colorectal cancer: a nationwide cohort study. Eur J Cancer. 2014; 50:447-56.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Mitry E, Guiu B, Cosconea S, Jooste V, et al. Epidemiology, management and prognosis of colorectal cancer with lung metastases: a 30-year population-based study. Gut. 2010; 59(10):1383-8.</mixed-citation>
     <mixed-citation xml:lang="en">Mitry E, Guiu B, Cosconea S, Jooste V, et al. Epidemiology, management and prognosis of colorectal cancer with lung metastases: a 30-year population-based study. Gut. 2010; 59(10):1383-8.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Tan KK, Lopes Gde L. Jr, Sim R, et al. How uncommon are isolated lung metastases in colorectal cancer? A review from database of 754 patients over 4 years. J Gastrointest Surg. 2009; 13:642- 648.</mixed-citation>
     <mixed-citation xml:lang="en">Tan KK, Lopes Gde L. Jr, Sim R, et al. How uncommon are isolated lung metastases in colorectal cancer? A review from database of 754 patients over 4 years. J Gastrointest Surg. 2009; 13:642- 648.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Clark JW, Grothey A. Systemic chemotherapy for nonoperable metastatic colorectal cancer: treatment recommendations. https://www.uptodate.com/contents/systemic-chemotherapy-for-nonoperable-metastatic-colorectal-cancer-treatment-recommendations ?search=systemic-chemotherapy-for-nonoperable-metastatic-colorectal-cancer-treatment&amp; source=search_result&amp;selected Title=1~150&amp;usage_type= default&amp;display_rank=1 (This topic last updated: Jan 13, 2020).</mixed-citation>
     <mixed-citation xml:lang="en">Clark JW, Grothey A. Systemic chemotherapy for nonoperable metastatic colorectal cancer: treatment recommendations. https://www.uptodate.com/contents/systemic-chemotherapy-for-nonoperable-metastatic-colorectal-cancer-treatment-recommendations ?search=systemic-chemotherapy-for-nonoperable-metastatic-colorectal-cancer-treatment&amp; source=search_result&amp;selected Title=1~150&amp;usage_type= default&amp;display_rank=1 (This topic last updated: Jan 13, 2020).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Blalock A. Recent advances in surgery. N Engl J Med. 1944;231:261-7.</mixed-citation>
     <mixed-citation xml:lang="en">Blalock A. Recent advances in surgery. N Engl J Med. 1944;231:261-7.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Pfannschmidt J, Dienemann H, Hoffmann H. Surgical resection of pulmonary metastases from colorectal cancer: a systematic review of published series. Ann Thorac Surg. 2007; 84:324-38.</mixed-citation>
     <mixed-citation xml:lang="en">Pfannschmidt J, Dienemann H, Hoffmann H. Surgical resection of pulmonary metastases from colorectal cancer: a systematic review of published series. Ann Thorac Surg. 2007; 84:324-38.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Pastorino U, Buyse M, Friedel G, et al. Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg. 1997; 113:37-49.</mixed-citation>
     <mixed-citation xml:lang="en">Pastorino U, Buyse M, Friedel G, et al. Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg. 1997; 113:37-49.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Timmerman RD, Bizekis CS, Pass HI, et al. Local surgical, ablative, and radiation treatment of metastases. CA Cancer J Clin. 2009;59 P145-70.</mixed-citation>
     <mixed-citation xml:lang="en">Timmerman RD, Bizekis CS, Pass HI, et al. Local surgical, ablative, and radiation treatment of metastases. CA Cancer J Clin. 2009;59 P145-70.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Gonzalez M, Ris H.B, Krueger T, Gervaz P. Colorectal cancer and thoracic surgeons: close encounters of the third kind. Expert RevAnticancer Ther. 2012;12:495-503.</mixed-citation>
     <mixed-citation xml:lang="en">Gonzalez M, Ris H.B, Krueger T, Gervaz P. Colorectal cancer and thoracic surgeons: close encounters of the third kind. Expert RevAnticancer Ther. 2012;12:495-503.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Treasure T. Pulmonary metastasectomy for colorectal cancer: weak evidence and no randomised trials. Eur J Cardiothorac Surg. 2008;33P300-2.</mixed-citation>
     <mixed-citation xml:lang="en">Treasure T. Pulmonary metastasectomy for colorectal cancer: weak evidence and no randomised trials. Eur J Cardiothorac Surg. 2008;33P300-2.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Inoue M, Kotake Y, Nakagawa K, Fujiwara K, et al.  Surgery for pulmonary metastases from colorectal carcinoma. Ann Thorac Surg. 2000;70:380-3.</mixed-citation>
     <mixed-citation xml:lang="en">Inoue M, Kotake Y, Nakagawa K, Fujiwara K, et al.  Surgery for pulmonary metastases from colorectal carcinoma. Ann Thorac Surg. 2000;70:380-3.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">McAfee MK, Allen MS, Trastek VF, Ilstrup DM, et al. Colorectal lung metastases: results of surgical excision. Ann Thorac Surg. 1992; 53:780-5.</mixed-citation>
     <mixed-citation xml:lang="en">McAfee MK, Allen MS, Trastek VF, Ilstrup DM, et al. Colorectal lung metastases: results of surgical excision. Ann Thorac Surg. 1992; 53:780-5.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B17">
    <label>17.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Regnard JF, Grunenwald D, Spaggiari L, et al. Surgical treatment of hepatic and pulmonary metastases from colorectal cancers. Ann Thorac Surg. 1998; 66:214-8.</mixed-citation>
     <mixed-citation xml:lang="en">Regnard JF, Grunenwald D, Spaggiari L, et al. Surgical treatment of hepatic and pulmonary metastases from colorectal cancers. Ann Thorac Surg. 1998; 66:214-8.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B18">
    <label>18.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Sakamoto T, Tsubota N, Iwanaga K, Yuki T, et al:ulmonary resection for metastases from colorectal cancer. Chest. 2001; 119:1069-72.</mixed-citation>
     <mixed-citation xml:lang="en">Sakamoto T, Tsubota N, Iwanaga K, Yuki T, et al:ulmonary resection for metastases from colorectal cancer. Chest. 2001; 119:1069-72.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B19">
    <label>19.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Carballo M, Maish M.S, Jaroszewski D.E, Holmes C.E. Videoassisted thoracic surgery (VATS) as a safe alternative for the resection of pulmonary metastases: a retrospective cohort study. J Cardiothorac Surg. 2009; 4:13.</mixed-citation>
     <mixed-citation xml:lang="en">Carballo M, Maish M.S, Jaroszewski D.E, Holmes C.E. Videoassisted thoracic surgery (VATS) as a safe alternative for the resection of pulmonary metastases: a retrospective cohort study. J Cardiothorac Surg. 2009; 4:13.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B20">
    <label>20.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chao YK, Chang HC, Wu YC, Liu Y.H, et al. Management of lung metastases from colorectal cancer: video-assisted thoracoscopic surgery versus thoracotomy-a casematched study. Thorac Cardiovasc Surg. 2012; 60:398-404.</mixed-citation>
     <mixed-citation xml:lang="en">Chao YK, Chang HC, Wu YC, Liu Y.H, et al. Management of lung metastases from colorectal cancer: video-assisted thoracoscopic surgery versus thoracotomy-a casematched study. Thorac Cardiovasc Surg. 2012; 60:398-404.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B21">
    <label>21.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Dong S, Zhang L, Li W, Du J, et al. Evaluation of videoassisted thoracoscopic surgery for pulmonary metastases: a metaanalysis. PLoS ONE. 2014; 9:329.</mixed-citation>
     <mixed-citation xml:lang="en">Dong S, Zhang L, Li W, Du J, et al. Evaluation of videoassisted thoracoscopic surgery for pulmonary metastases: a metaanalysis. PLoS ONE. 2014; 9:329.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B22">
    <label>22.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Nakajima J, Murakawa T, Fukami T, Takamoto S. Is thoracoscopic surgery justified to treat pulmonary metastasis from colorectal cancer?. Interact Cardiovasc Thorac Surg. 2008; 7:212-6.</mixed-citation>
     <mixed-citation xml:lang="en">Nakajima J, Murakawa T, Fukami T, Takamoto S. Is thoracoscopic surgery justified to treat pulmonary metastasis from colorectal cancer?. Interact Cardiovasc Thorac Surg. 2008; 7:212-6.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B23">
    <label>23.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Nakas A, Klimatsidas M.N, Entwisle J, Martin-Ucar A.E, et al. Video-assisted versus open pulmonary metastasectomy: the surgeon’s finger or the radiologist’s eye?. Eur J Cardiothorac Surg. 2009; 36:469-74</mixed-citation>
     <mixed-citation xml:lang="en">Nakas A, Klimatsidas M.N, Entwisle J, Martin-Ucar A.E, et al. Video-assisted versus open pulmonary metastasectomy: the surgeon’s finger or the radiologist’s eye?. Eur J Cardiothorac Surg. 2009; 36:469-74</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B24">
    <label>24.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ibrahim T, Tselikas L, Yazbeck C, Kattan J. Systemic versus local therapies for colorectal cancer pulmonary metastasis: what to choose and when?. J Gastrointest  Cancer 2016; 47:223-31.</mixed-citation>
     <mixed-citation xml:lang="en">Ibrahim T, Tselikas L, Yazbeck C, Kattan J. Systemic versus local therapies for colorectal cancer pulmonary metastasis: what to choose and when?. J Gastrointest  Cancer 2016; 47:223-31.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B25">
    <label>25.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Van Cutsem E, Cervantes A, Adam R, et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol 2016; 27:1386-422.</mixed-citation>
     <mixed-citation xml:lang="en">Van Cutsem E, Cervantes A, Adam R, et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol 2016; 27:1386-422.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B26">
    <label>26.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Hiraki T, Gobara H, Iguchi T, Fujiwara H, et al. Radiofrequency ablation as treatment for pulmonary metastasis of colorectal cancer. World J Gastroenterol. 2014; 20:988-96.</mixed-citation>
     <mixed-citation xml:lang="en">Hiraki T, Gobara H, Iguchi T, Fujiwara H, et al. Radiofrequency ablation as treatment for pulmonary metastasis of colorectal cancer. World J Gastroenterol. 2014; 20:988-96.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B27">
    <label>27.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Legras A, Mordant P, Cazes A, Riquet M.. Radiofrequency of lung metastases: should initial pneumothorax predict treatment failure?. Rev Pneumol Clin. 2013; 69:336-9.</mixed-citation>
     <mixed-citation xml:lang="en">Legras A, Mordant P, Cazes A, Riquet M.. Radiofrequency of lung metastases: should initial pneumothorax predict treatment failure?. Rev Pneumol Clin. 2013; 69:336-9.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B28">
    <label>28.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Matsui Y, Hiraki T, Gobara H, et al. Long-term survival following percutaneous radiofrequency ablation of colorectal lungmetastases. J Vasc Interv Radiol. 2015; 26:303-10.</mixed-citation>
     <mixed-citation xml:lang="en">Matsui Y, Hiraki T, Gobara H, et al. Long-term survival following percutaneous radiofrequency ablation of colorectal lungmetastases. J Vasc Interv Radiol. 2015; 26:303-10.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B29">
    <label>29.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Schneider T. Thermal ablation of malignant lung tumours. Zentralbl Chir. 2015;140:104-8.</mixed-citation>
     <mixed-citation xml:lang="en">Schneider T. Thermal ablation of malignant lung tumours. Zentralbl Chir. 2015;140:104-8.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B30">
    <label>30.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Takahashi W, Nakajima M, Yamamoto N, et al. Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study. Radiat Oncol. 2014;9:68.</mixed-citation>
     <mixed-citation xml:lang="en">Takahashi W, Nakajima M, Yamamoto N, et al. Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study. Radiat Oncol. 2014;9:68.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B31">
    <label>31.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Yan TD, King J, Sjarif A, Glenn D, et al.  Learning curve for percutaneous radiofrequency ablation of pulmonary metastases from colorectal carcinoma: a prospective study of 70 consecutive cases. Ann Surg Oncol. 2006;13:1588-95.</mixed-citation>
     <mixed-citation xml:lang="en">Yan TD, King J, Sjarif A, Glenn D, et al.  Learning curve for percutaneous radiofrequency ablation of pulmonary metastases from colorectal carcinoma: a prospective study of 70 consecutive cases. Ann Surg Oncol. 2006;13:1588-95.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B32">
    <label>32.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Yan TD, King J, Sjarif A, Glenn D, et al. Percutaneous radiofrequency ablation of pulmonary metastases from colorectal carcinoma: prognostic determinants for survival. Ann Surg Oncol. 2006; 13:1529-37.</mixed-citation>
     <mixed-citation xml:lang="en">Yan TD, King J, Sjarif A, Glenn D, et al. Percutaneous radiofrequency ablation of pulmonary metastases from colorectal carcinoma: prognostic determinants for survival. Ann Surg Oncol. 2006; 13:1529-37.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B33">
    <label>33.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Nahum Goldberg S, Dupuy D.E. Image-guided radiofrequency tumor ablation: challenges and opportunities-part I. J Vasc Interv Radiol. 2001;12:1021-32.</mixed-citation>
     <mixed-citation xml:lang="en">Nahum Goldberg S, Dupuy D.E. Image-guided radiofrequency tumor ablation: challenges and opportunities-part I. J Vasc Interv Radiol. 2001;12:1021-32.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B34">
    <label>34.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Hiraki T, Gobara H, Mimura H, et al. Radiofrequency ablation of lung cancer at Okayama University Hospital: a review of 10 years of experience. Acta Med Okayama. 2011; 65:287-97.</mixed-citation>
     <mixed-citation xml:lang="en">Hiraki T, Gobara H, Mimura H, et al. Radiofrequency ablation of lung cancer at Okayama University Hospital: a review of 10 years of experience. Acta Med Okayama. 2011; 65:287-97.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B35">
    <label>35.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">de Baere T, Tselikas L, Pearson E, et al. Interventional oncology for liver and lung metastases from colorectal cancer: the current state of the art. Diagn Interv Imaging. 2015;96:647-54.</mixed-citation>
     <mixed-citation xml:lang="en">de Baere T, Tselikas L, Pearson E, et al. Interventional oncology for liver and lung metastases from colorectal cancer: the current state of the art. Diagn Interv Imaging. 2015;96:647-54.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B36">
    <label>36.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ferguson J, Alzahrani N, Zhao J, Glenn D, et al. Long term results of RFA to lung metastases from colorectal cancer in 157 patients. Eur J Surg Oncol. 2015;41:690-5</mixed-citation>
     <mixed-citation xml:lang="en">Ferguson J, Alzahrani N, Zhao J, Glenn D, et al. Long term results of RFA to lung metastases from colorectal cancer in 157 patients. Eur J Surg Oncol. 2015;41:690-5</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B37">
    <label>37.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chi A, Liao Z, Nguyen NP, Xu J, et al. Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: clinical implications. Radiother Oncol. 2010;94:1-11</mixed-citation>
     <mixed-citation xml:lang="en">Chi A, Liao Z, Nguyen NP, Xu J, et al. Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: clinical implications. Radiother Oncol. 2010;94:1-11</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B38">
    <label>38.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Fuks Z, Kolesnick R. Engaging the vascular component of the tumor response. Cancer Cell. 2005;8:89-91</mixed-citation>
     <mixed-citation xml:lang="en">Fuks Z, Kolesnick R. Engaging the vascular component of the tumor response. Cancer Cell. 2005;8:89-91</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B39">
    <label>39.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Carvajal C, Navarro-Martin A, Cacicedo J, Ramos R, et al. Stereotactic body radiotherapy for colorectal lung oligometastases: preliminary single institution results. J BUON. 2015;20:158-65.</mixed-citation>
     <mixed-citation xml:lang="en">Carvajal C, Navarro-Martin A, Cacicedo J, Ramos R, et al. Stereotactic body radiotherapy for colorectal lung oligometastases: preliminary single institution results. J BUON. 2015;20:158-65.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B40">
    <label>40.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Filippi AR, Badellino S, Ceccarelli M, et al. Stereotactic ablative radiation therapy as first local therapy for lung oligometastases from colorectal cancer: a single-institution cohort study. Int J Radiat Oncol Biol Phys. 2015;91:524-9</mixed-citation>
     <mixed-citation xml:lang="en">Filippi AR, Badellino S, Ceccarelli M, et al. Stereotactic ablative radiation therapy as first local therapy for lung oligometastases from colorectal cancer: a single-institution cohort study. Int J Radiat Oncol Biol Phys. 2015;91:524-9</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B41">
    <label>41.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Takeda A, Sanuki N, Kunieda E. Role of stereotactic body radiotherapy for oligometastasis from colorectal cancer. World J Gastroenterol. 2014;20:4220-9</mixed-citation>
     <mixed-citation xml:lang="en">Takeda A, Sanuki N, Kunieda E. Role of stereotactic body radiotherapy for oligometastasis from colorectal cancer. World J Gastroenterol. 2014;20:4220-9</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B42">
    <label>42.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Rusthoven KE, Kavanagh BD, Burri SH, et al. Multiinstitutional phase I/II trial of stereotactic body radiation therapy for lung metastases. J Clin Oncol. 2009;27:1579-84</mixed-citation>
     <mixed-citation xml:lang="en">Rusthoven KE, Kavanagh BD, Burri SH, et al. Multiinstitutional phase I/II trial of stereotactic body radiation therapy for lung metastases. J Clin Oncol. 2009;27:1579-84</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B43">
    <label>43.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Widder J, Klinkenberg TJ, Ubbels JF, Wiegman E.M, et al. Pulmonary oligometastases: metastasectomy or stereotactic ablative radiotherapy?. Radiother Oncol. 2013;107:409-13</mixed-citation>
     <mixed-citation xml:lang="en">Widder J, Klinkenberg TJ, Ubbels JF, Wiegman E.M, et al. Pulmonary oligometastases: metastasectomy or stereotactic ablative radiotherapy?. Radiother Oncol. 2013;107:409-13</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B44">
    <label>44.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Schlijper RC, Grutters JP, Houben R, et al. What to choose as radical local treatment for lung metastases from colo-rectal cancer: surgery or radiofrequency ablation?. Cancer Treat Rev. 2014;40:60-7.</mixed-citation>
     <mixed-citation xml:lang="en">Schlijper RC, Grutters JP, Houben R, et al. What to choose as radical local treatment for lung metastases from colo-rectal cancer: surgery or radiofrequency ablation?. Cancer Treat Rev. 2014;40:60-7.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
