Safety in Technosphere Safety in Technosphere Безопасность в техносфере 1998-071X 30678 10.12737/article_5d8b217fe8f138.98731914 Аналитический обзор Analytical review Аналитический обзор Practical Use of Green Nanotechnologies and Bionanoparticles in the Treatment and Diagnosis of Various Diseases Практическое использование «зеленых» нанотехнологий и бионаночастиц в терапии и диагностике различных заболеваний Семина Полина Николаевна Semina Polina Nikolaevna polina_semina@mail.ru

кандидат физико-математических наук;

candidate of physical and mathematical sciences;

 Благодатова А. В. Blagodatova A. V.

кандидат биологических наук;

candidate of sciences in biology;

 https://orcid.org/0000-0002-9715-3323 Антропова Ирина Геннадьевна Antropova Irina Gennad'evna antropovai@inbox.ru

кандидат химических наук;

candidate of chemical sciences;

 Смолянский А. С. Smolyanskiy A. S. assafic@gmail.com

кандидат химических наук;

candidate of chemical sciences;

 Сибирский государственный университет науки и технологий имени академика М.Ф. Решетнева Россия Сибирский государственный университет науки и технологий имени академика М.Ф. Решетнева Russian Federation Красноярский государственный медицинский университет им. проф. В. Ф. Войно-Ясенецкого Минздрава России Россия Krasnoyarsk State Medical University named after Prof. V. F. Voino- Yasenetsky (Ministry of Health of the Russian Federation) Russian Federation Российский химико-технологичсекий университет имени Д.И. Менделеева Москва Россия D.Mendeleev University of Chemical Technology of Russia Moscow Russian Federation Российский химико-технологичсекий университет имени Д.И. Менделеева Москва Россия D.Mendeleev University of Chemical Technology of Russia Moscow Russian Federation Российский химико-технологический университет им. Д.И. Менделеева D.Mendeleyev University of Chemical Technology of Russia Филиал АО «Ордена Трудового Красного Знамени научно-исследовательский физико-химический институт имени Л. Я. Карпова» Россия Leading Researcher, Branch of JSC «Karpov Institute of Physical Chemistry» Russian Federation РХТУ им. Д. И. Менделеева Россия Dmitry Mendeleev University of Chemical Technology of Russia Russian Federation 7 5 49 72 https://naukaru.ru/en/nauka/article/30678/view

Рассмотрены биомедицинские аспекты применения наноматериалов, полученных методами «зеленых» нанотехнологий, для диагностики и терапии различных заболеваний. Отмечены следующие достоинства «зеленых» наноматериалов: низкая стоимость продукта, малая длительность производственного цикла, безопасность, возможность функционализации поверхности НЧ в процессе изготовления. Обсуждены проблемы в развитии «зеленых» нанотехнологий, обусловленные, в первую очередь, отсутствием мер по стандартизации и классификации наблюдаемых терапевтических эффектов в зависимости от особенностей синтеза, структуры и свойств «зеленых» наноматериалов. Показана перспективность использования «зеленых» наноматериалов в лечении онкологических заболеваний методами фотодинамической и фототермической терапии, магнитно-резонансной томографии, создании биосенсоров и антибактериальных покрытий на поверхности материалов медицинского назначения для борьбы с возбудителями инфекционных заболеваний и т. д. Отмечена возможность направленного синтеза «зеленых» наноматериалов для создания персонально-ориентированных лекарственных препаратов. Сделано заключение, что медицина будущего — это, прежде всего, персонифицированная мультифункциональная медицина, задачей которой является профилактика, высокоточная и своевременная диагностика, низкоинвазивное, быстрое и эффективное лечение и индивидуальный безопасный медикаментозный период реабилитации, в которой широкое применение найдут лекарственные препараты и методы лечения, созданные на основе «зеленых» нанотехнологий и бионаночастиц.

The biomedical aspects for the use of nanomaterials obtained by «green nanotechnologies» methods for the diagnosis and treatment of various diseases have been considered. The following advantages of «green nanomaterials» have been noted: product’s low cost, production cycle’s short duration, safety, possibility of the nanoparticle surface modification during manufacturing process. Problems in the «green nanotechnologies» development have been discussed, primarily caused by the lack of measures for standardization and classification of observed therapeutic effects depending on synthesis peculiarities, structure and properties of «green nanomaterials». It has been shown the prospects for the «green nanomaterials» use in the treatment of oncological diseases by methods of photodynamic and photothermal therapy, magnetic resonance imaging, creation of biosensors and antibacterial coatings on the surface of medical materials for the fight against infectious agents, etc. The possibility of «green nanomaterials» directed synthesis for the creation of personal-oriented drugs has been noted. It has been concluded that the medicine of future is, first of all, the personalized multifunctional one, the task of which is prevention, high-precision and timely diagnosis, as well as low-invasive, fast and effective treatment, and an individual safe pharmacological period of rehabilitation, in which drugs and treatment methods based on «green nanomaterials and nanotechnologies» will be widely used.

 металл оксид наночастица бионаночастица растение микроорганизм экстракт восстановление синтез свойства медицина терапия диагностика коллоид раствор metal oxide nanoparticle bionanoparticle plant microorganism extract recovery synthesis properties medicine therapy diagnostics colloid solution

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