SELECTED CELLULAR IMMUNITY INDICATORS IN DIAGNOSTICS OF ACUTE MESENTERIAL ISCHEMIA
Rubrics: SURGERY & NEUROSURGERY
Authors:
1.
Chita, Chita, Russian Federation
2.
Chita, Chita, Russian Federation
Type:
Article
Pages:
from 92
to 95
Status:
Published
Received:
14.11.2017
Accepted:
30.11.2017
Published:
30.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
mezenterial'naya ishemiya, kletochnyy immunitet, diagnostika, eksperiment
Abstract (English):
Ostraya mezenterial'naya ishemiya v nastoyaschee vremya zanimaet odno iz lidiruyuschih mest po pokazatelyu le- tal'nosti sredi ostryh hirurgicheskih zabolevaniy. V svyazi s etim poisk laboratornogo kriteriya, kotoryy s bol'shey veroyatnost'yu otrazhal by dinamiku dannogo patologicheskogo sostoyaniya, predstavlyaet interes. Vmeste s tem do 80 % vseh immunokompetentnyh kletok lokalizovany v slizistoy obolochke kishechnika. Pri etom pervym bar'erom na puti proniknoveniya v organizm antigenov yavlyayutsya vnutriepitelial'- nye limfocity. Poslednie predstavleny v osnovnom CD8-kletkami. To est' mozhno predpolozhit', chto okklyuziya mezenterial'nogo rusla, ravno kak i ego reperfuziya, privedut k izmeneniyam v subpopulyacionnoy strukture limfocitov. Cel'yu issledovaniya yavilos' izuchenie nekotoryh pokazateley subpopulyacionnoy struktury limfocitov na razlichnyh stadiyah ostroy mezenterial'noy ishemii v eksperimente. Materialy i metody. Na modeli ostroy mezenterial'noy ishemii byli izucheny absolyutnoe i otnosi- tel'noe chislo limfocitov, CD4-, CD8-kletok, a takzhe sootnoshenie CD4/CD8. Rezul'taty issledovaniya. Vyyavleno, chto polnaya okklyuziya kranial'noy bryzheechnoy arterii soprovozhda- etsya snizheniem urovnya limfocitov, uvelicheniem otnosheniya CD4/CD8. Zaklyuchenie. V usloviyah ostroy neobratimoy ishemii kishechnika nablyudaetsya progressivnoe snizhenie obschego chisla limfocitov venoznoy krovi s razvitiem disbalansa v ih subpopulyacii. Po soderzhaniyu CD4- i CD8-kletok, sootnosheniyu CD4/CD8 mozhno sudit' o stadii ostroy mezenterial'noy ishemii. Na osnovanii poluchennyh dannyh razrabotan sposob diagnostiki ostroy mezenterial'noy ishemii, ob'ektivno otrazha- yuschiy funkcional'nuyu aktivnost' immunnoy sistemy v zavisimosti ot intensivnosti destruktivnyh processov v stenke kishechnika (Patent № 2552338, Rossiyskaya Federaciya).
Ostraya mezenterial'naya ishemiya v nastoyaschee vremya zanimaet odno iz lidiruyuschih mest po pokazatelyu le- tal'nosti sredi ostryh hirurgicheskih zabolevaniy. V svyazi s etim poisk laboratornogo kriteriya, kotoryy s bol'shey veroyatnost'yu otrazhal by dinamiku dannogo patologicheskogo sostoyaniya, predstavlyaet interes. Vmeste s tem do 80 % vseh immunokompetentnyh kletok lokalizovany v slizistoy obolochke kishechnika. Pri etom pervym bar'erom na puti proniknoveniya v organizm antigenov yavlyayutsya vnutriepitelial'- nye limfocity. Poslednie predstavleny v osnovnom CD8-kletkami. To est' mozhno predpolozhit', chto okklyuziya mezenterial'nogo rusla, ravno kak i ego reperfuziya, privedut k izmeneniyam v subpopulyacionnoy strukture limfocitov. Cel'yu issledovaniya yavilos' izuchenie nekotoryh pokazateley subpopulyacionnoy struktury limfocitov na razlichnyh stadiyah ostroy mezenterial'noy ishemii v eksperimente. Materialy i metody. Na modeli ostroy mezenterial'noy ishemii byli izucheny absolyutnoe i otnosi- tel'noe chislo limfocitov, CD4-, CD8-kletok, a takzhe sootnoshenie CD4/CD8. Rezul'taty issledovaniya. Vyyavleno, chto polnaya okklyuziya kranial'noy bryzheechnoy arterii soprovozhda- etsya snizheniem urovnya limfocitov, uvelicheniem otnosheniya CD4/CD8. Zaklyuchenie. V usloviyah ostroy neobratimoy ishemii kishechnika nablyudaetsya progressivnoe snizhenie obschego chisla limfocitov venoznoy krovi s razvitiem disbalansa v ih subpopulyacii. Po soderzhaniyu CD4- i CD8-kletok, sootnosheniyu CD4/CD8 mozhno sudit' o stadii ostroy mezenterial'noy ishemii. Na osnovanii poluchennyh dannyh razrabotan sposob diagnostiki ostroy mezenterial'noy ishemii, ob'ektivno otrazha- yuschiy funkcional'nuyu aktivnost' immunnoy sistemy v zavisimosti ot intensivnosti destruktivnyh processov v stenke kishechnika (Patent № 2552338, Rossiyskaya Federaciya).
Keywords:
mezenterial'naya ishemiya, kletochnyy immunitet, diagnostika, eksperiment
mezenterial'naya ishemiya, kletochnyy immunitet, diagnostika, eksperiment
1. Znachenie nekotoryh pokazateley kletochnogo immuniteta
