ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS
Rubrics: MICROBIOLOGY AND VIROLOGY
Authors:
1.
Irkutsk State Medical Academy of Postgraduate Education
(Department of Epidemiology and Microbiology, Professor)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
2.
Irkutsk State Medical Academy of Postgraduate Education
(Department of Epidemiology and Microbiology, Teaching Assistant)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Irkutsk State Medical Academy of Postgraduate Education
(Department of Epidemiology and Microbiology, Teaching Assistant)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
4.
Scientific Center for Human Reproduction and Family Health Problems
(Laboratory of Epidemiologically and Socially Significant Infections, Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 45
to 47
Status:
Published
Received:
27.10.2017
Accepted:
02.11.2017
Published:
02.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
Klebsiella pneumoniae, antibiotikorezistentnost', cefalosporiny
Abstract (English):
Klebsiella rneumoniae otnosyatsya k gruppe naibolee rasprostranennyh i opasnyh vozbuditeley infekcionnyh bolezney cheloveka. Nesomnennyy interes predstavlyaet izuchenie ih rezistentnosti k β-laktamnym antibiotikam, v chastnosti, k cefalosporinam, shiroko ispol'zuemym v antiinfekcionnoy terapii. Cel' raboty: izuchenie ustoychivosti K. rneumoniae k cefalosporinam. Materialy i metody. Issledovano 50 shtammov K. rneumoniae, izolirovannyh ot bol'nyh, nahodyaschihsya na lechenii v Irkutskoy oblastnoy klinicheskoy bol'nice v 2015 g. (mokrota, lavazhnaya zhidkost', krov'), a takzhe iz sekcionnogo materiala. Rezistentnost' k chetyrem antibiotikam (cefotaksim, ceftriakson, ceftazidim, cefepim) opredelyali disko-diffuzionnym metodom. Rezul'taty issledovaniya. Ustanovleno, chto k cefalosporinam III pokoleniya byli ustoychivy 56,0–62,0 % shtammov K. rneumoniae; k preparatu IV pokoleniya – 58,0 % shtammov. Naibolee vysokaya rezistentnost' byla vyyavlena v otnoshenii ceftazidima (rezistentny 62,0 % shtammov; umerenno rezistentny – 20,0 %). Spektr ustoychivosti ko vsem chetyrem antibiotikam vyyavlen u 52,0 % shtammov; perekrestnaya ustoychivost' k preparatam cefalosporinovogo ryada – u 64,0 %. Ustoychivost' izolyatov iz sekcionnogo materiala byla vyshe, chem u klebsiell, izolirovannyh iz organov i tkaney bol'nyh. Klebsielly, vydelennye iz lavazhnoy zhidkosti, chasche (p < 0,05) proyavlyali rezistentnost' k preparatam cefalosporinovogo ryada, po sravneniyu so shtammami, izolirovannymi iz mokroty. Zaklyuchenie. Shtammy Klebsiella rneumoniae harakterizuyutsya znachitel'nym urovnem rezistentnosti k β-laktamnym antibiotikam cefalosporinovogo ryada.
Klebsiella rneumoniae otnosyatsya k gruppe naibolee rasprostranennyh i opasnyh vozbuditeley infekcionnyh bolezney cheloveka. Nesomnennyy interes predstavlyaet izuchenie ih rezistentnosti k β-laktamnym antibiotikam, v chastnosti, k cefalosporinam, shiroko ispol'zuemym v antiinfekcionnoy terapii. Cel' raboty: izuchenie ustoychivosti K. rneumoniae k cefalosporinam. Materialy i metody. Issledovano 50 shtammov K. rneumoniae, izolirovannyh ot bol'nyh, nahodyaschihsya na lechenii v Irkutskoy oblastnoy klinicheskoy bol'nice v 2015 g. (mokrota, lavazhnaya zhidkost', krov'), a takzhe iz sekcionnogo materiala. Rezistentnost' k chetyrem antibiotikam (cefotaksim, ceftriakson, ceftazidim, cefepim) opredelyali disko-diffuzionnym metodom. Rezul'taty issledovaniya. Ustanovleno, chto k cefalosporinam III pokoleniya byli ustoychivy 56,0–62,0 % shtammov K. rneumoniae; k preparatu IV pokoleniya – 58,0 % shtammov. Naibolee vysokaya rezistentnost' byla vyyavlena v otnoshenii ceftazidima (rezistentny 62,0 % shtammov; umerenno rezistentny – 20,0 %). Spektr ustoychivosti ko vsem chetyrem antibiotikam vyyavlen u 52,0 % shtammov; perekrestnaya ustoychivost' k preparatam cefalosporinovogo ryada – u 64,0 %. Ustoychivost' izolyatov iz sekcionnogo materiala byla vyshe, chem u klebsiell, izolirovannyh iz organov i tkaney bol'nyh. Klebsielly, vydelennye iz lavazhnoy zhidkosti, chasche (p < 0,05) proyavlyali rezistentnost' k preparatam cefalosporinovogo ryada, po sravneniyu so shtammami, izolirovannymi iz mokroty. Zaklyuchenie. Shtammy Klebsiella rneumoniae harakterizuyutsya znachitel'nym urovnem rezistentnosti k β-laktamnym antibiotikam cefalosporinovogo ryada.
Keywords:
Klebsiella pneumoniae, antibiotikorezistentnost', cefalosporiny
Klebsiella pneumoniae, antibiotikorezistentnost', cefalosporiny
1. antibiotikoustoychivost' spislit
