MODERN CONCEPTS OF THE PATHOGENESIS OF POLYCYSTIC OVARY SYNDROME (LITERATURE REVIEW)
Rubrics: OBSTETRICS & GYNAECOLOGY
Authors:
1.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Physiology and Pathology of Endocrine System, Junior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
2.
Nauchnyy centr problem zdorov'ya sem'i i reprodukcii cheloveka
(laboratoriya fiziologii i patologii endokrinnoy sistemy, ispolnyayuschaya obyazannosti mladshego nauchnogo sotrudnika)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Physiology and Pathology of Endocrine System, Senior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
4.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Gynecological Endocrinology, Junior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
5.
Nauchnyy centr problem zdorov'ya sem'i i reprodukcii cheloveka
(laboratoriya fiziologii i patologii endokrinnoy sistemy, zaveduyuschiy)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 9
to 14
Status:
Published
Received:
23.10.2017
Accepted:
02.11.2017
Published:
02.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
sindrom polikistoznyh yaichnikov, gormony, giperandrogeniya, insulinorezistentnost'
Abstract (English):
Sindrom polikistoznyh yaichnikov (SPKYa), takzhe izvestnyy kak sindrom Shteyna – Leventalya yavlyaetsya odnim iz naibolee rasprostranennyh ginekologicheskih rasstroystv, kotoroe zatragivaet 5–20 % molodyh zhenschin vo vsem mire v raznyh etnicheskih gruppah i rasah i chasto yavlyaetsya prichinoy besplodiya, vykidysha, oslozhneniy vo vremya beremennosti i rodov. SPKYa predstavlyaet soboy polisimptomaticheskoe zabolevanie, harakterizuyuscheesya giperandrogenizmom, menstrual'noy disfunkciey, narusheniem vyrabotki zhenskih polovyh gormonov i kistoznymi izmeneniyami yaichnikov pri ul'trazvukovom issledovanii. Osnovnye proyavleniya SPKYa lezhat v osnove diagnosticheskih kriteriev Nacional'nogo instituta zdorov'ya SShA (NIH) i Evropeyskogo obschestva reproduktologii i embriologii cheloveka, a takzhe Amerikanskogo obschestva reproduktivnoy mediciny (ESHRE/ASRM). V sootvetstvii s etimi kriteriyami suschestvuet neskol'ko razlichnyh fenotipov sindroma polikistoznyh yaichnikov. V to zhe vremya SPKYa yavlyaetsya metabolicheskim rasstroystvom. Dokazana rol' rezistentnosti k insulinu v razvitii etogo sostoyaniya. Vsledstvie etogo patogenez, diagnostika i lechenie predstavlyayut interes ne tol'ko dlya ginekologov, no takzhe i dlya endokrinologov, kardiologov i drugih vrachey, poskol'ku SPKYa predstavlyaet soboy ser'eznuyu problemu, svyazannuyu s ozhireniem, povyshennymi riskami adenokarcinomy endometriya, gipertoniey i serdechno-sosudistymi oslozhneniyami, saharnym diabetom 2-go tipa i drugimi ser'eznymi posledstviyami. Na segodnyashniy den' mnogie issledovateli razlichnyh stran aktivno izuchayut mehanizmy formirovaniya SPKYa. V nashey stat'e predstavlen obzor nauchnyh istochnikov, posvyaschennyh probleme sindroma polikistoznyh yaichnikov, osvescheny sovremennye predstavleniya ob etiologii i patogeneze dannogo zabolevaniya, harakternye klinicheskie proyavleniya i sovremennye podhody k diagnostike SPKYa.
Sindrom polikistoznyh yaichnikov (SPKYa), takzhe izvestnyy kak sindrom Shteyna – Leventalya yavlyaetsya odnim iz naibolee rasprostranennyh ginekologicheskih rasstroystv, kotoroe zatragivaet 5–20 % molodyh zhenschin vo vsem mire v raznyh etnicheskih gruppah i rasah i chasto yavlyaetsya prichinoy besplodiya, vykidysha, oslozhneniy vo vremya beremennosti i rodov. SPKYa predstavlyaet soboy polisimptomaticheskoe zabolevanie, harakterizuyuscheesya giperandrogenizmom, menstrual'noy disfunkciey, narusheniem vyrabotki zhenskih polovyh gormonov i kistoznymi izmeneniyami yaichnikov pri ul'trazvukovom issledovanii. Osnovnye proyavleniya SPKYa lezhat v osnove diagnosticheskih kriteriev Nacional'nogo instituta zdorov'ya SShA (NIH) i Evropeyskogo obschestva reproduktologii i embriologii cheloveka, a takzhe Amerikanskogo obschestva reproduktivnoy mediciny (ESHRE/ASRM). V sootvetstvii s etimi kriteriyami suschestvuet neskol'ko razlichnyh fenotipov sindroma polikistoznyh yaichnikov. V to zhe vremya SPKYa yavlyaetsya metabolicheskim rasstroystvom. Dokazana rol' rezistentnosti k insulinu v razvitii etogo sostoyaniya. Vsledstvie etogo patogenez, diagnostika i lechenie predstavlyayut interes ne tol'ko dlya ginekologov, no takzhe i dlya endokrinologov, kardiologov i drugih vrachey, poskol'ku SPKYa predstavlyaet soboy ser'eznuyu problemu, svyazannuyu s ozhireniem, povyshennymi riskami adenokarcinomy endometriya, gipertoniey i serdechno-sosudistymi oslozhneniyami, saharnym diabetom 2-go tipa i drugimi ser'eznymi posledstviyami. Na segodnyashniy den' mnogie issledovateli razlichnyh stran aktivno izuchayut mehanizmy formirovaniya SPKYa. V nashey stat'e predstavlen obzor nauchnyh istochnikov, posvyaschennyh probleme sindroma polikistoznyh yaichnikov, osvescheny sovremennye predstavleniya ob etiologii i patogeneze dannogo zabolevaniya, harakternye klinicheskie proyavleniya i sovremennye podhody k diagnostike SPKYa.
Keywords:
sindrom polikistoznyh yaichnikov, gormony, giperandrogeniya, insulinorezistentnost'
sindrom polikistoznyh yaichnikov, gormony, giperandrogeniya, insulinorezistentnost'
1. 1Panarina OV.22.05.17docx
