THE FEATURES OF REPRODUCTIVE HEALTH OF WOMEN WITH MULTIPLE SCLEROSIS
Rubrics: OBSTETRICS & GYNAECOLOGY
Authors:
1.
Siberian State Medical University
(Department of Obstetrics and Gynecology, Professor)
Tomsk, Tomsk, Russian Federation
Tomsk, Tomsk, Russian Federation
2.
Tomsk, Tomsk, Russian Federation
3.
Siberian State Medical University
(Department of Neurology and Neurosurgery, Head)
Tomsk, Tomsk, Russian Federation
Tomsk, Tomsk, Russian Federation
Type:
Article
Pages:
from 26
to 31
Status:
Published
Received:
19.10.2017
Accepted:
22.11.2017
Published:
22.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
rasseyannyy skleroz, beremennost', reproduktivnoe zdorov'e, polovye steroidy
Abstract (English):
Vvedenie: Zabolevaemost' rasseyannym sklerozom (RS) v 2 raza vyshe u zhenschin, a debyut zabolevaniya prihoditsya na molodoy reproduktivnyy vozrast, chto obuslovlivaet aktual'nost' problemy. Cel': Ocenit' osobennosti reproduktivnogo zdorov'ya zhenschin s RS v razlichnye vozrastnye periody. Material i metody: Provedeno prospektivnoe issledovanie v parallel'nyh gruppah i issledovanie sluchay-kontrol' zhenschin rannego i pozdnego reproduktivnogo vozrasta s dostovernym diagnozom RS. Rezul'taty: Vo vremya beremennosti vyyavleno dostovernoe snizhenie chastoty obostreniy RS v sravnenii s predgravidarnym periodom, a chastota patologii beremennosti i oslozhneniy techeniya rodov ne prevyshayut populyacionnye pokazateli. Dobrovol'noe besplodie i bezdetnost' zaregistrirovany u 21,3% i 32% zhenschin, sootvetstvenno. Povyshenie koncentracii follikulostimuliruyuschego gormona (FSG) sootvetstvuet uvelicheniyu stepeni invalidizacii po rasshirennoy shkale invalidizacii Kurtcke (EDSS) i prodolzhitel'nosti zabolevaniya; snizhenie koncentracii digidroepiandrosterona sul'fata (DGEA-S) sootvetstvuet bolee vysokoy stepeni invalidizacii po shkale EDSS i prodolzhitel'nosti zabolevaniya. Zaklyuchenie: Beremennost' okazyvaet protektivnoe deystvie na klinicheskoe techenie RS. Besplodie v bol'shinstve sluchaev nosit dobrovol'nyy harakter, no vmeste s tem u zhenschin s RS uzhe v rannem reproduktivnom vozraste nablyudayutsya gipergonadotropnoe sostoyanie i gipoandrogeniya, chto ukazyvaet na snizhenie steroidosinteticheskoy funkcii yaichnikov i mozhet sluzhit' prichinoy narusheniya fertil'nosti.
Vvedenie: Zabolevaemost' rasseyannym sklerozom (RS) v 2 raza vyshe u zhenschin, a debyut zabolevaniya prihoditsya na molodoy reproduktivnyy vozrast, chto obuslovlivaet aktual'nost' problemy. Cel': Ocenit' osobennosti reproduktivnogo zdorov'ya zhenschin s RS v razlichnye vozrastnye periody. Material i metody: Provedeno prospektivnoe issledovanie v parallel'nyh gruppah i issledovanie sluchay-kontrol' zhenschin rannego i pozdnego reproduktivnogo vozrasta s dostovernym diagnozom RS. Rezul'taty: Vo vremya beremennosti vyyavleno dostovernoe snizhenie chastoty obostreniy RS v sravnenii s predgravidarnym periodom, a chastota patologii beremennosti i oslozhneniy techeniya rodov ne prevyshayut populyacionnye pokazateli. Dobrovol'noe besplodie i bezdetnost' zaregistrirovany u 21,3% i 32% zhenschin, sootvetstvenno. Povyshenie koncentracii follikulostimuliruyuschego gormona (FSG) sootvetstvuet uvelicheniyu stepeni invalidizacii po rasshirennoy shkale invalidizacii Kurtcke (EDSS) i prodolzhitel'nosti zabolevaniya; snizhenie koncentracii digidroepiandrosterona sul'fata (DGEA-S) sootvetstvuet bolee vysokoy stepeni invalidizacii po shkale EDSS i prodolzhitel'nosti zabolevaniya. Zaklyuchenie: Beremennost' okazyvaet protektivnoe deystvie na klinicheskoe techenie RS. Besplodie v bol'shinstve sluchaev nosit dobrovol'nyy harakter, no vmeste s tem u zhenschin s RS uzhe v rannem reproduktivnom vozraste nablyudayutsya gipergonadotropnoe sostoyanie i gipoandrogeniya, chto ukazyvaet na snizhenie steroidosinteticheskoy funkcii yaichnikov i mozhet sluzhit' prichinoy narusheniya fertil'nosti.
Keywords:
rasseyannyy skleroz, beremennost', reproduktivnoe zdorov'e, polovye steroidy
rasseyannyy skleroz, beremennost', reproduktivnoe zdorov'e, polovye steroidy
1. Spislit reproduktivnoe zdorov'e skleroz
