GENES OF PATHOGENICITY OF BACTERIA OF THE GENUS ENTEROCOCCUS, ISOLATED FROM THE VAGINAL BIOTOPE OF WOMEN WITH CHRONIC ENDOMETRITIS AND REPRODUCTIVE DISORDERS
Rubrics: MICROBIOLOGY AND VIROLOGY
Authors:
2.
Nauchnyy centr problem zdorov'ya sem'i i reprodukcii cheloveka
(laboratoriya patofiziologii, veduschiy nauchnyy sotrudnik)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Microecology and Microbiome, Head)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
5.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Socially Significant Infections in Repro ductive Medicine, Head)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 88
to 92
Status:
Published
Received:
19.10.2017
Accepted:
22.11.2017
Published:
22.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
hronicheskiy endometrit, vaginal'nyy biotop, uslovno-patogennaya mikrobiota, enterokokki, geny patogennosti
Abstract (English):
Mikroflora vlagalischa igraet vazhnuyu rol' i ee sleduet rassmatrivat' kak svoeobraznuyu ekologicheskuyu sistemu, reagiruyuschuyu na lyubye izmeneniya sostoyaniya organizma zhenschiny. Klinicheski vyrazhennye genital'nye infekcii etiologicheski svyazany s uslovno-patogennymi mikroorganizmami. V patogeneze razvitiya disbiozov vazhnuyu rol' igrayut ne tol'ko kolichestvennye i kachestvennye izmeneniya v mikroflore, no i «patogennyy potencial» mikroorganizmov. Provedeno mikrobiologicheskoe issledovanie mikrobioty vlagalischa u zhenschin s hronicheskim endometritom i reproduktivnymi narusheniyami. V issledovanie byli vklyucheny 63 zhenschiny s hronicheskim endometritom (HE) i 39 zhenschin gruppy sravneniya (bez HE). Pokazano, chto mikroekologicheskie narusheniya v vaginal'nom biotope u zhenschin obeih grupp harakterizuyutsya deficitom normoflory (laktobakteriy) i shirokim spektrom uslovno-patogennyh vidov. Vyyavlena chastota vstrechaemosti vzyatyh v issledovanie genov patogennosti u bakteriy roda Enterococcus, vydelennyh iz vaginal'nogo biotopa zhenschin. Shtammy enterokokkov (E. faecium i E. faecalis), vydelennye u zhenschin s HE, yavlyayutsya rezervuarom geneticheskih determinant genov patogennosti (efaA, asa 1, sprE), podtverzhdaya izvestnye dannye o bol'shem potenciale patogennosti u dannyh vidov bakteriy. Geny (efaA,asa1), osuschestvlyayuschie nachal'nyy etap inficirovaniya organizma–hozyaina byli detektirovany u enterokokkov vaginal'nogo biotopa v 12,5% i tol'ko u zhenschin s HE. Gen serinovoy proteinazy (sprE), otvechayuschiy za proniknovenie i razrushenie tkaney, detektirovali takzhe tol'ko u zhenschin s HE v 37,5%.
Mikroflora vlagalischa igraet vazhnuyu rol' i ee sleduet rassmatrivat' kak svoeobraznuyu ekologicheskuyu sistemu, reagiruyuschuyu na lyubye izmeneniya sostoyaniya organizma zhenschiny. Klinicheski vyrazhennye genital'nye infekcii etiologicheski svyazany s uslovno-patogennymi mikroorganizmami. V patogeneze razvitiya disbiozov vazhnuyu rol' igrayut ne tol'ko kolichestvennye i kachestvennye izmeneniya v mikroflore, no i «patogennyy potencial» mikroorganizmov. Provedeno mikrobiologicheskoe issledovanie mikrobioty vlagalischa u zhenschin s hronicheskim endometritom i reproduktivnymi narusheniyami. V issledovanie byli vklyucheny 63 zhenschiny s hronicheskim endometritom (HE) i 39 zhenschin gruppy sravneniya (bez HE). Pokazano, chto mikroekologicheskie narusheniya v vaginal'nom biotope u zhenschin obeih grupp harakterizuyutsya deficitom normoflory (laktobakteriy) i shirokim spektrom uslovno-patogennyh vidov. Vyyavlena chastota vstrechaemosti vzyatyh v issledovanie genov patogennosti u bakteriy roda Enterococcus, vydelennyh iz vaginal'nogo biotopa zhenschin. Shtammy enterokokkov (E. faecium i E. faecalis), vydelennye u zhenschin s HE, yavlyayutsya rezervuarom geneticheskih determinant genov patogennosti (efaA, asa 1, sprE), podtverzhdaya izvestnye dannye o bol'shem potenciale patogennosti u dannyh vidov bakteriy. Geny (efaA,asa1), osuschestvlyayuschie nachal'nyy etap inficirovaniya organizma–hozyaina byli detektirovany u enterokokkov vaginal'nogo biotopa v 12,5% i tol'ko u zhenschin s HE. Gen serinovoy proteinazy (sprE), otvechayuschiy za proniknovenie i razrushenie tkaney, detektirovali takzhe tol'ko u zhenschin s HE v 37,5%.
Keywords:
hronicheskiy endometrit, vaginal'nyy biotop, uslovno-patogennaya mikrobiota, enterokokki, geny patogennosti
hronicheskiy endometrit, vaginal'nyy biotop, uslovno-patogennaya mikrobiota, enterokokki, geny patogennosti
1. Spislit geny patogennosti
