In the experimental conditions the possibility of increasing the resistance of rats to physical influence in the conditions of the use of a mixture of adaptogenic products (Hypericum perforatum and Rhodiola rosea) under cold and heat stress was studied. The animals were divided into 9 groups, each of them had 10 rats: the 1st group had intact animals which were held in standard conditions of vivarium; the 2nd group was the control group in which rats were exposed to cold during three hours daily (-15ºC, 50% humidity); the 3rd was the control group in which rats were exposed to heat during 45 minutes daily (+40ºC, 50% humidity); the 4th, 6th, 8th groups were the experimental groups in which before cooling animals had a daily intake of powder mixture of Hypericum perforatum and Rhodiola rosea in a dose of 30 mg/kg, 150 mg/kg, 300 mg/kg, respectively; the 5th, 7th, 9th groups were the experimental groups in which rats before being put in the heat climatic chamber were given a daily intake of powder mixture of Hypericum perforatum and Rhodiola rosea in a dose of 30 mg/kg, 150 mg/kg, 300 mg/kg, respectively. It was found out that cold and heat exposure reduces the resistance of experimental animals (in different degrees) to swimming in all the days of the experiment. Thus the length of swimming of intact animals was 146±3.4 min; whereas in animals under cold exposure in the control group it was 108±5.6 min, and under the exposure to heat it was 105±3.4 min (p<0.01). The introduction of a mixture of Hypericum perforatum and Rhodiola rosea into the food of animals, exposed to temperature effects in a dose of 150-300 mg/kg increased swimming time under exposure to cold up to 178±4.7 min (р<0.05) and under exposure to heat up to 181±3.0 min (р<0.05). At the 14th day the average duration of swimming of rats which took the mixture at a dose of 150-300 mg/kg against exposure to cold and heat was 192±3.0 min and 188±5.9 min, respectively. A similar trend was observed till the 28th day of research. Thus, the use of a mixture of Hypericum perforatum and Rhodiola rosea in conditions of prolonged heat and cold stress on the organism of experimental animals leads to significant increase in the resistance of rats to fatigue.
adaptogens, cold stress, heat stress, resistance of organism, fatigue, physical performance.
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