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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Acta biomedica scientifica</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Acta biomedica scientifica</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Acta biomedica scientifica</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2541-9420</issn>
   <issn publication-format="online">2587-9596</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">14237</article-id>
   <article-id pub-id-type="doi">10.12737/23031</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>Лекции</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>Lecture</subject>
    </subj-group>
    <subj-group>
     <subject>Лекции</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">HISTOLOGICAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF BRAIN MENINGIOMAS</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ГИСТОЛОГИЧЕСКАЯ И ИММУНОГИСТОХИМИЧЕСКАЯ ХАРАКТЕРИСТИКА МЕНИНГИОМ ГОЛОВНОГО МОЗГА</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Cороковиков </surname>
       <given-names>Владимир  Алексеевич </given-names>
      </name>
      <name xml:lang="en">
       <surname>Corokovikov </surname>
       <given-names>Vladimir  Алексеевич </given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Степанов </surname>
       <given-names>Иван  Андреевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Stepanov </surname>
       <given-names>Ivan  Андреевич</given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Бывальцев </surname>
       <given-names>Вадим  Анатольевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Byvaltsev </surname>
       <given-names>Vadim  Анатольевич</given-names>
      </name>
     </name-alternatives>
     <email>byval75vadim@yandex.ru</email>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Антипина </surname>
       <given-names>Светлана  Львовна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Antipina </surname>
       <given-names>Svetlana  Львовна</given-names>
      </name>
     </name-alternatives>
    </contrib>
   </contrib-group>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2016-12-03T00:00:00+03:00">
    <day>03</day>
    <month>12</month>
    <year>2016</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2016-12-03T00:00:00+03:00">
    <day>03</day>
    <month>12</month>
    <year>2016</year>
   </pub-date>
   <volume>1</volume>
   <issue>4</issue>
   <fpage>187</fpage>
   <lpage>194</lpage>
   <self-uri xlink:href="https://naukaru.ru/en/nauka/article/14237/view">https://naukaru.ru/en/nauka/article/14237/view</self-uri>
   <abstract xml:lang="ru">
    <p>Для менингиом, группы опухолей, происходящих из мозговых оболочек, присущ большой спектр морфологических характеристик, определяющих тип и степень злокачественности. Исследование анапластических менингиом представляет сложность, так как они имеют сходство с мягкотканными злокачественными новообразованиями. Иммуноокрашивание позволяет не только определить цитогенетический источник и степень злокачественности опухоли, но и обнаружить патологические белки – продукты транскрипции повреждённых участков ДНК и дать рекомендации по назначению таргетной терапии</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Meningiomas are among the most common primary intracranial tumors. They arise from meningothelial cells of the arachnoid layer that forms the external lining of the brain and occur primarily at the base of the skull in the parasellar regions as well as over the cerebral convexities. Of particular difficulty are anaplastic meningiomas, having similarities with malignant soft tissue tumors. Immunostaining allows to define not only the source of cytogenetic, tumor grade, but detect abnormal proteins – transcription products damaged DNA regions and make recommendations for the appointment of targeted therapy. Targeted effect on the meningioma will allow to achieve a significant increase in patient survival</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>менингиома</kwd>
    <kwd>доброкачественная</kwd>
    <kwd>типическая</kwd>
    <kwd>атипическая</kwd>
    <kwd>анапластическая</kwd>
    <kwd>иммуногистохимия</kwd>
    <kwd>маркёры</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>meningioma</kwd>
    <kwd>benign</kwd>
    <kwd>typical</kwd>
    <kwd>typical</kwd>
    <kwd>anaplastic</kwd>
    <kwd>immunohistochemistry</kwd>
    <kwd>markers</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
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