The article provides comparative law analysis of constitutional legal statuses of Presidents of the Republic of Uzbekistan and the USA. The analysis is conducted per respective provisions of the constitutions of the countries in question and per such criteria as form of government, form of rule, presidential elections and powers, qualifications, established for candidates for presidency. Thus, special attention is paid to various peculiarities of the legal status of the institute of presidency of the countries in question, in particular, regarding such issues as participation in the formation of the upper chamber of parliament, ministries and other State administrative bodies, interaction with the parliament and the judicial branch, powers in defense and security sectors, international relations, law making etc. Thus, the author identifies such distinctive features of the institute of presidency in Uzbekistan, as the existence of the post of Prime Minister and responsibility of the Government before the parliament and President; that the President possesses arbitration and integrative, coordinating and guaranteeing functions; the right to legislative initiative, dissolution of Parliament, convocation of the referendum, appointing and dismissing heads of local executive authorities; the status of President allows holding office of a Senate member during good behavior upon the expiry of the term. On the basis of an astute comparative analysis the author also reveals a number of similar characteristics in the institutes of presidency in the USA and Uzbekistan, such as age qualifications, the right to the address to parliament, participation of the Senate in appointing, approving and electing functionaries, presented by President, the veto power, as well as the status of the Commander-in-Chief.