Russian Federation
Sankt-Peterburg, St. Petersburg, Russian Federation
Tula, Tula, Russian Federation
UDC 61
Introduction. Breast cancer (BC) is a rare oncological disease that accounts for less than 1% of all cases of breast malignancies and less than 0.5% of the total structure of oncological pathology in men. Breast cancer in men is a serious medical and diagnostic problem. The diagnosis of breast cancer in the early stages is difficult, differential diagnosis is carried out primarily with gynecomastia with glandular duct hyperplasia. The diagnosis of breast cancer in men in advanced stages is not difficult. X-ray mammography, ultrasound, and biopsy with histological and immunohistochemical examination of the material are used in the diagnosis of breast cancer in men. The main treatment method for the primary operable and locally advanced form of breast cancer is surgical. Treatment tactics are determined by the stage of the disease, the molecular biological subtype of the tumor, the patient's age and concomitant pathology. The purpose of the study. To evaluate the current state of diagnosis and treatment of this pathology using the example of a clinical case of breast cancer in a man. Materials and methods. The paper presents a clinical case of breast cancer in a man. The results and their discussion. The above clinical case of breast cancer in a man demonstrates the importance of a multimodal approach (visualization, histological examination, IHC examination) for verifying the diagnosis and choosing the right treatment tactics. Conclusions. Based on the analysis of modern literature and the given clinical case for practical application, it is advisable: – Introduction of screening ultrasound programs for men with gynecomastia. – Mandatory use of the BI-RADS scale for standardization of reports. – A molecular study of all cases of breast cancer in men. – Informing male patients about the need to seek help for any breast complaints, especially if a lump is found in it.
mammary gland, breast cancer in men, gynecomastia, immunohistochemistry, hormone receptor status, biopsy, ultrasound diagnostics, X-ray mammography.
1. Goncharov A.V., Gavrilov E.N., Chernin'kaya N.A. Ul'trazvukovoe issledovanie v diagnostike ginekomastii: opyt klinicheskoy praktiki // Tihookeanskiy medicinskiy zhurnal. 2024. № 3 (97). S. 75-78.
2. Tyulyandin S.A., Artamonova E.V., Zhigulev A.N. i dr. Rak molochnoy zhelezy. Prakticheskie rekomendacii RUSSCO, chast' 1.2. //Zlokachestvennye opuholi. 2024. Tom 14, № 3s2. S. 32-81.
3. Hodorovich O.S., Solodkiy V.A., Astaturyan K.S. i dr. Rak molochnoy zhelezy u muzhchin. klinicheskiy opyt FGBU "Rossiyskiy Nauchnyy Centr Rentgenoradiologii" Minzdrava Rossii // Opuholi zhenskoy reproduktivnoy sistemy. 2023. Tom 19, № 2. S. 94-103.
4. Chestnova T.V., Shatirishvili M.I., Romashkina N.V. i dr. Epidemiologiya lyuminal'nogo gormonozavisimogo raka molochnoy zhelezy i rol' molekulyarno-geneticheskogo issledovaniya gena PIK3CA (obzor literatury) // Vestnik novyh med. tehnologiy. 2024. Tom. 31, № 1. S. 91-94.
5. Ajmani A., Witheiler D. W., Kivelevitch D. Carcinoma erysipeloides secondary to male breast cancer in a patient with BRCA1 and BRCA2 mutations: a clinical presentation and management //BMJ Case Reports CP. 2025. Vol. 18, № 4. P. e264429.
6. Al Assaad M., Michaud O., Semaan A. et al. Whole-genome sequencing analysis of male breast cancer unveils novel structural events and potential therapeutic targets // Modern Pathology. 2024. Vol. 37, № 4. R. 100452.
7. Bhardwaj P.V. Gupta S., Elyash A. et al. Male breast cancer: a review on diagnosis, treatment, and survivorship //Current Oncology Reports. 2024. Vol. 26, № 1. R. 34-45.
8. Chidambaram A., Prabhakaran R., Sivasamy S. et al. Male breast Cancer: current scenario and future perspectives // Technology in cancer research & treatment. 2024, № 23. R. 15330338241261836.
9. Pyo Y., Kwon K.H. Estrogen receptors, hormonal imbalance, gynecomastia, hyperestrogenemia, and male breast cancer: a literature review // Journal of men's health. 2024. Vol. 20, № 9. R. 1-9.
10. Silvestri V., Valentini V., Bucalo A. et al. HER2-low expression in male breast cancer: results from a multicenter series in Italy // Cancers. 2024. Vol.16, № 3. R. 548.
11. Thomas M., Al Kashroom H., Reddy S. et al. Male breast cancer: imaging considerations for diagnosis and surveillance // Journal of clinical medicine research. 2024. Vol. 16, № 5. R. 197.
12. Valentini V., Bucalo A., Conti G. et al. Gender-specific genetic predisposition to breast cancer: BRCA genes and beyond // Cancers. 2024. Vol.16, № 3. R. 579.
