Clinical Medicine and Pharmacology Clinical Medicine and Pharmacology Клиническая медицина и фармакология 2409-3750 102893 10.12737/2409-3750-2025-11-2-27-34 Обзоры reviews Обзоры Aprotinin and mefenamic acid in the treatment of malignant neoplasms: a literature review Место апротинина и мефенаминовой кислоты в комплексном лечении злокачественных новообразований (обзор литературы) Радыгина Л. В. Radygina L. V. Барыбкина М. Н. Barybkina M. N. Всероссийский институт научной и технической информации Российской академии наук Россия Всероссийский институт научной и технической информации Российской академии наук Russian Federation Всероссийский институт научной и технической информации Российской академии наук Россия Всероссийский институт научной и технической информации Российской академии наук Russian Federation 01 08 2025 01 08 2025 11 2 27 34 01 08 2025 https://naukaru.ru/en/nauka/article/102893/view

В России и мире увеличивается число случаев злокачественных новообразований и смертей от него. Поэтому важно искать новые методы лечения онкологических заболеваний. Цель исследования: изучить возможности применения апротинина и мефенаминовой кислоты для лечения злокачественных новообразований. Мы проанализировали статьи из электронных библиотек e-library.ru, cyberleninka.ru и PubMed. Выбрали наиболее значимые работы на русском и английском языках, где описаны исследования этих препаратов в онкологии. Протеазы играют важную роль в росте, развитии и распространении опухолей. Матриксные металлопротеиназы разрушают внеклеточный матрикс, что способствует росту опухоли и метастазированию. Система плазминоген-плазмин также участвует в этих процессах. Апротинин блокирует активность сериновых протеаз, включая матриксные металлопротеиназы и систему плазминоген-плазмин. Мефенаминовая кислота оказывает цитотоксическое действие на клетки злокачественных опухолей. Апротинин и мефенаминовая кислота могут быть эффективны в комплексном лечении злокачественных новообразований, особенно когда традиционные методы терапии не помогают.

The incidence of malignant neoplasms and deaths from them is increasing in Russia and worldwide. Therefore, it is important to look for new methods of treating oncological diseases. The aim of the study was to study the possibilities of using aprotinin and mefenamic acid for the treatment of malignant neoplasms. We analyzed articles from the electronic libraries e-library.ru, cyberleninka.ru and PubMed. We selected the most significant works in Russian and English, which described studies of these drugs in oncology. Proteases play an important role in the growth, development and spread of tumors. Matrix metalloproteinases destroy the extracellular matrix, which contributes to tumor growth and metastasis. The plasminogen-plasmin system is also involved in these processes. Aprotinin blocks the activity of serine proteases, including matrix metalloproteinases and the plasminogen-plasmin system. Mefenamic acid has a cytotoxic effect on malignant tumor cells. Aprotinin and mefenamic acid may be effective in the complex treatment of malignant neoplasms, especially when traditional methods of therapy do not help.

 злокачественные новообразования протеазы матриксные металлопротеиназы система плазминоген-плазмин апротинин мефенаминовая кислота malignant neoplasms proteases matrix metalloproteinases plasminogen-plasmin system aprotinin mefenamic acid

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