Technical reality is a set technical and technological objects and processes. This reality widens recently up to the world of material and artificial objects, phenomena and processes, oversteps the limits of techniques and approaches the concept of technosphere. This extensive concept itself includes the whole of artificial, lifeless, realmaterial and field, electromagnetic world. At the beginning of the XXI-st to change a technical reality began a more complicated reality. It is already different - extranatural, extrabiospheric, not neutral to biosophere and its animate nature, but transforming or even destroying a secular biospheric life. The formed in the paper new concept –“mancaused”, on the one hand, includes technical reality giving a new life not only to man, but also to terrestrial life precipitating not only processes of social development, but also socionatural one. On the other hand such a reality correlates with biosphere and human life in a different way – subjects it to pathological transformations and, as a result, to annihilation. It is necessary to investigate in a system way the formation of a mancaused reality by various institutes of the Russian Academy of Sciences, and also to create a United Institute of Prospective Regional Development in Bryansk State Technical University on basis of scientificphilosophical school for researches of integrated socialtechnonatural processes of life development.